204716-17-6

Basic information

• Product Name: FMOC-D, L-PHE(4-C(O)NH2)
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-(4-CARBOXAMIDOPHENYL)ALANINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-P-CARBOXAMIDO-L-PHENYLALANINE;FMOC-L-4-CARBAMOYLPHE;FMOC-L-4-CARBAMOYLPHENYLALANINE;FMOC-D, L-PHE(4-C(O)NH2);FMOC-PHE(P-CONH2)-OH;FMOC-PHE(4-CONH2)-OH;FMOC-L-PHE(4-C(O)NH2)
• CAS NO: 204716-17-6
• Molecular Formula: C₂₅H₂₂N₂O₅
• Molecular Weight: 430.45
• Product Categories: Phenylalanine analogs and other aromatic alpha amino acids
• Mol File: 204716-17-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 713.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.336±0.06 g/cm3(Predicted)
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: FMOC-D, L-PHE(4-C(O)NH2)(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D, L-PHE(4-C(O)NH2)(204716-17-6)
• EPA Substance Registry System: FMOC-D, L-PHE(4-C(O)NH2)(204716-17-6)

Safety Data

• Hazardous Substances Data: 204716-17-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 223593-01-9 (S)-2-Benzyloxycarbonylamino-3-(4-carbamoyl-phenyl)-propionic acid benzyl ester 
• 183070-42-0 4-((S)-2-Benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-benzoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 223593-04-2 l-4-carbamoylphenylalanine 

Downstream Products

• 623950-14-1 {1-(4-carbamoyl-benzyl)-2-oxo-2-[2-(4-phenyl-1H-imidazol-2-yl)-piperidin-1-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

A selective method for the preparation of primary amides: Synthesis of Fmoc-L-4 carboxamidophenylalanine and other compounds

A new method for the synthesis of primary amides was developed in which carboxylic acids were treated with ammonium chloride in the presence of peptide synthesis coupling agents and base at room temperature. These mild conditions allow the conversion of carboxyl groups to primary amides on substrates possessing sensitive functional groups such as esters and the base-labile Fmoc protecting group.