2048-10-4

Basic information

• Product Name: 1H-Pyrrole, 3,4-bis(4-methoxyphenyl)-
• CAS NO: 2048-10-4
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Mol File: 2048-10-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 3,4-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 3,4-bis(4-methoxyphenyl)-(2048-10-4)
• EPA Substance Registry System: 1H-Pyrrole, 3,4-bis(4-methoxyphenyl)-(2048-10-4)

Safety Data

• Hazardous Substances Data: 2048-10-4(Hazardous Substances Data)

Usage

Class

Pyrrole derivatives

Structure

Contains a pyrrole ring with two 4-methoxyphenyl groups attached at positions 3 and 4

Usage

Organic synthesis, pharmaceutical research

Potential pharmacological activities

Anticancer, antimicrobial

Electronic properties

Interesting electronic properties that make it suitable for use in organic electronic materials.

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 93362-54-0 3,4-dibromo-1--1H-pyrrole 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 2234-38-0 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid 
• 246868-68-8 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 29559-26-0 (p-methoxyphenyl)nitromethane 
• 1041424-88-7 3,4-di(4-methoxyphenyl)-1H-pyrrol-2-carboxylic acid 
• 6443-74-9 p-methoxy-α-p-methoxyphenylcinnamonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 
• 343823-36-9 meso-2,3-bis(p-methoxyphenyl)succinonitrile 
• 1357168-93-4 3,4-di(4-methoxyphenyl)-1-tosylpyrrole 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 

Downstream Products

• 1357169-01-7 (C₃HO₂BF₂)(C₄H₂N((C₆H₄)OCH₃)2)2 
• 1357168-98-9 1,3-bis(3,4-di(4-methoxyphenyl)pyrrol-2-yl)-1,3-propanedione 
• 170238-94-5 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 170238-96-7 methyl 3,4-bis(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-pyrrole-2-carboxylate 
• 65112-26-7 (3,4-bis(4-methoxyphenyl)-1H-pyrrol-1-yl)(phenyl)methanone 
• 1418216-89-3 3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole 
• 1261079-21-3 1,3,4-tris(4-methoxyphenyl)-1H-pyrrole 

Relevant articles and documents

Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-OH-Neo A could attenuate the accum

Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, respectively. The results showed that neolamellarin A 1 (IC50 = 10.8 ± 1.0 μM) and derivative 2b (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biological activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small molecule probes for target protein identification.

Pyrrole marine alkaloid Neolamellarin A analogs and its preparation method and application

The invention relates to pyrrole ocean alkaloids Neolamellarin A analogues as shown in the formula I and a preparation method and application thereof. Experiments show that, some of the pyrrole ocean alkaloids Neolamellarin A analogues have strong inhibitory effect on tumor cell lines; some of the pyrrole ocean alkaloids Neolamellarin A analogues have very good neuro cell protective effect; and some of the pyrrole ocean alkaloids Neolamellarin A analogues have very strong inhibitory effect on heat shock protein Hsp90.