205040-01-3

Basic information

• Product Name: N-(2-chloro-4-cyanophenyl)-8-hydroxyquinoline-7-carboxamide
• Synonyms: N-(2-chloro-4-cyanophenyl)-8-hydroxyquinoline-7-carboxamide
• CAS NO: 205040-01-3
• Molecular Weight: 323.738
• Mol File: 205040-01-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-chloro-4-cyanophenyl)-8-hydroxyquinoline-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-4-cyanophenyl)-8-hydroxyquinoline-7-carboxamide(205040-01-3)
• EPA Substance Registry System: N-(2-chloro-4-cyanophenyl)-8-hydroxyquinoline-7-carboxamide(205040-01-3)

Safety Data

• Hazardous Substances Data: 205040-01-3(Hazardous Substances Data)

Upstream product

• 21803-75-8 4-amino-3-chlorobenzonitrile 
• 19829-79-9 8-hydroxy-7-quinolinecarboxylic acid 

Relevant articles and documents

SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway

Disruption of cyclic adenosine monophosphate response element binding protein (CREB) provides a potential new strategy to address acute leukemia, a disease associated with poor prognosis, and for which conventional treatment options often carry a significant risk of morbidity and mortality. We describe the structure-activity relationships (SAR) for a series of XX-650-23 derived from naphthol AS-E phosphate that disrupts binding and activation of CREB by the CREB-binding protein (CBP). Through the development of this series, we identified several salicylamides that are potent inhibitors of acute leukemia cell viability through inhibition of CREB-CBP interaction. Among them, a biphenyl salicylamide, compound 71, was identified as a potent inhibitor of CREB-CBP interaction with improved physicochemical properties relative to previously described derivatives of naphthol AS-E phosphate.

8-hydroxy-7-substituted quinolines as anti-viral agents

The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula III These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).