2051-97-0Relevant articles and documents
Synthesis of a poly(ethylene glycol)-supported tetrakis ammonium salt: A recyclable phase-transfer catalyst of improved catalytic efficiency
Benaglia, Maurizio,Cinquini, Mauro,Cozzi, Franco,Tocco, Graziella
, p. 3391 - 3393 (2002)
The immobilization of four quaternary ammonium groups on a poly(ethylene glycol) support provided an efficient and recyclable phase-transfer catalyst.
Pyrrole synthesis using a tandem Grubbs' carbene-RuCl3 catalytic system
Dieltiens, Nicolai,Stevens, Christian V.,Vos, David De,Allaert, Bart,Drozdzak, Renata,Verpoort, Francis
, p. 8995 - 8998 (2004)
A straightforward pyrrole synthesis from diallylamines is developed by using a tandem catalyst system leading to ring-closing metathesis with the second generation Grubbs' catalyst (10%) followed by dehydrogenation in the presence of RuCl3 × H2O (2%).
A new method to N-arylmethylenepyrroles from N-acylpyrroles
D'Silva, Claudius,Iqbal, Rifat
, p. 457 - 458 (1996)
An efficient general method for the preparation of N-arylmethylenepyrroles based on the reduction of N-acylpyrroles is reported. The reduction procedure described is sufficiently mild to make it applicable to a variety of sensitive acyl and heterocyclic acyl compounds where reduction results in cleavage of the C-N bond. The method can also be used in the preparation of pyrrole derivatives containing base sensitive protecting groups.
Development of Pd(OAc)2-catalyzed tandem oxidation of C[sbnd]N, C[sbnd]C, and C(sp3)–H bonds: Concise synthesis of 1-aroylisoquinoline, oxoaporphine, and 8-oxyprotoberberine alkaloids
Nishimoto, Saeko,Nakahashi, Hiromichi,Toyota, Masahiro
, (2020/11/13)
A catalytic tandem oxidation of C[sbnd]N, C[sbnd]C, and C(sp3)–H bonds is developed. This tandem oxidation is applied to two-step total syntheses of papaveraldine and pulcheotine A. Additionally, the total synthesis of liriodenine is achieved in six steps from homopiperonyl alcohol and 2-bromophenylacetonitrile by applying this catalytic tandem oxidation. Moreover, the direct conversion of xylopinine to 8-oxypseudopalmatine in a 76% yield demonstrates the versatility of this catalytic reaction.
Lactam derivatives and preparation method and application thereof
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Paragraph 0066-0070, (2020/02/10)
The invention relates to lactam derivatives and a preparation method and application thereof. Compared with the prior art, the invention provides lactam compounds with a novel structure. The compoundsand compositions thereof have remarkable activity in inhibition of the proliferation of cancer cells (including, but not limited to, the liver cancer cell line HepG2 and the lung cancer cell line A549), and the activity of multiple compounds is in the same order of magnitude as the activity of the commercial drug adriamycin or superior to the activity of adriamycin. The compounds of the inventioncan be prepared from N-substituted pyrrole compounds through a reaction, and the preparation method is convenient, rapid and efficient.
Multifunctional 2- and 3-Fluoropyrroles
Heeran, Darren,Sandford, Graham
supporting information, p. 2339 - 2343 (2019/02/27)
Sequential reaction cascades for the synthesis of polysubstituted 2- and 3-fluoropyrrole derivatives from common polybromopyrrole precursors have been developed. A strategic variation of a combination of regioselective debromolithiation followed by trapping of the corresponding carbanions by electrophilic fluorination and Pd catalysed cross-coupling reactions allows access to polyfunctional fluoropyrrole products by methodology applicable to drug discovery programs, extending the range of five-membered fluoroazaheteroaromatic derivatives potentially available for incorporation into screening libraries.
