205242-33-7

Basic information

• Product Name: benzyl-(2-tert-butyl-phenyl)-amine
• Synonyms: benzyl-(2-tert-butyl-phenyl)-amine
• CAS NO: 205242-33-7
• Molecular Weight: 239.36
• Mol File: 205242-33-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: benzyl-(2-tert-butyl-phenyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-(2-tert-butyl-phenyl)-amine(205242-33-7)
• EPA Substance Registry System: benzyl-(2-tert-butyl-phenyl)-amine(205242-33-7)

Safety Data

• Hazardous Substances Data: 205242-33-7(Hazardous Substances Data)

Upstream product

• 6310-21-0 2-(1,1-dimethylethyl)-benzenamine 
• 100-39-0 benzyl bromide 
• 391653-64-8 N-benzylidene-2-tert-butyl-aniline 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 

Downstream Products

• 205242-36-0 1-benzyl-8-tert-butyl-4,4-dimethyl-6-pentanoyl-1,2,3,4-tetrahydroquinoline 
• 205242-02-0 1-Benzyl-6-bromo-8-tert-butyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline 
• 205242-00-8 1-Benzyl-8-tert-butyl-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one 
• 205242-35-9 1-Benzyl-8-tert-butyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline 
• 205242-34-8 N-benzyl-N-(2-tert-butylphenyl)-3,3-dimethylacrylamide 

Relevant articles and documents

Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols

A series of air-stable N-heterocyclic carbene (NHC) Ir(III) complexes (Ir1-6), bearing various combinations of chlorine, pyridine and NHC ligands, were assayed for the N-alkylation of amines with alcohols. It was found that Ir3, with two monodentate 1,3-bis-methyl-imidazolylidene (IMe) ligands, emerged as the most active complex. A large variety of amines and primary alcohols were efficiently converted into mono-N-alkylated amines in 53–96% yields. As a special highlight, for the challenging MeOH, selective N-monomethylation could be achieved using KOH as a base under an air atmosphere. Moreover, this catalytic system was successfully applied to the gram-scale synthesis of some valuable compounds.

N-Alkylation of Amines with Alcohols Catalyzed by Manganese(II) Chloride or Bromopentacarbonylmanganese(I)

A manganese-catalyzed N-alkylation reaction of amines with alcohols via hydrogen autotransfer strategy has been demonstrated. The developed practical catalytic system including an inexpensive, nontoxic, commercially available MnCl2 or MnBr(CO)5 as the metal salt and triphenylphosphine as a ligand provides access to diverse aromatic, heteroaromatic, and aliphatic secondary amines in moderate-to-high yields. In addition, this operationally simple protocol is scalable to the gram level and suitable for synthesizing heterocycles such as indole and resveratrol-derived amines known to be active for Alzheimer's disease.

A bifunctional strategy for N-heterocyclic carbene-stabilized iridium complex-catalyzed: N -alkylation of amines with alcohols in aqueous media

Through the strategy of combining bifunctional 2-hydroxypyridine and a thermally stable N-heterocyclic carbene ligand, an Ir-catalyzed N-monoalkylation reaction has been developed in aqueous media under base-free conditions. This reaction proceeds smoothly with high yields of various aromatic amines and sulfonamides with a wide range of primary alcohols. Experimental and computational studies revealed a metal-ligand cooperative mechanism and its thermal stability during the bifunctional catalysis in aqueous media.