205381-75-5Relevant articles and documents
Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii
Chao, María N.,Matiuzzi, Carolina Exeni,Storey, Melissa,Li, Catherine,Szajnman, Sergio H.,Docampo, Roberto,Moreno, Silvia N. J.,Rodriguez, Juan B.
, p. 1094 - 1108 (2015/06/08)
Abstract As a part of our project aimed at searching for new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC-9 (4-phenoxyphenoxyethyl thiocyanate), which were modified at the te
Synthesis of a new class of difunctional tetraphenylene crown ethers
Gibson, Harry W.,Nagvekar, Devdatt S.,Delaviz, Yadollah,Bryant, William S.
, p. 1429 - 1436 (2007/10/03)
Three new substituted tetraphenylene crown ethers have been made. Bis(5- carbomethoxy-1,3-phenylene)-bis(p-phenylene)-(3x + 6)-crown-x, where x = 12, 16, and 20 (11b-11d) were synthesized via [1 + 1] cyclization of methyl 3,5- bis[ω-chloro(oligoethyleneoxy)]benzoates (13b-3d) with methyl 3,5-bis[ω- (p-hydroxyphenoxy)(oligoethyleneoxy)]benzoates (16b-6d) using K2CO3 as base and tetrabutylammonium iodide as a phase transfer agent in dimethylformamide (DMF). The corresponding 30-membered (x = 8) macrocycle 11a could not be made by this approach; only the elimination product, 3,5-bis(vinyloxy)benzoic acid (19), was isolated. 16a-16d were made via alkylation of p-benzyloxyphenol (14) with 13a-13d, respectively, followed by hydrogenolysis with Pd/C as catalyst. No complexation of these macrocycles with dibenzylammonium ions was detected by NMR spectroscopy, but weak complexation of 11d with a paraquat derivative was observed.