205445-53-0 Usage
General Description
BOC-D-3,5-DIFLUOROPHE is a chemical compound with the molecular formula C18H21F2NO4. It is a derivative of 3,5-difluorophenylacetic acid (Diflunisal) and is often used in medicinal chemistry and pharmaceutical research. BOC-D-3,5-DIFLUOROPHE is commonly employed as a building block in the synthesis of various pharmaceutical compounds and is known for its potential therapeutic applications. BOC-D-3,5-DIFLUOROPHE may also be utilized in the development of new drug candidates and in the study of structure-activity relationships in drug design. Furthermore, BOC-D-3,5-DIFLUOROPHE is valued for its stability and compatibility with standard laboratory procedures, making it a versatile tool in chemical and biological research.
Check Digit Verification of cas no
The CAS Registry Mumber 205445-53-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,4,4 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 205445-53:
(8*2)+(7*0)+(6*5)+(5*4)+(4*4)+(3*5)+(2*5)+(1*3)=110
110 % 10 = 0
So 205445-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H17F2NO4/c1-14(2,3)21-13(20)17-11(12(18)19)6-8-4-9(15)7-10(16)5-8/h4-5,7,11H,6H2,1-3H3,(H,17,20)(H,18,19)/t11-/m1/s1
205445-53-0Relevant articles and documents
Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.
scheme or table, p. 5607 - 5612 (2010/11/17)
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.
