205587-50-4

Basic information

• Product Name: (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester
• Synonyms: (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester
• CAS NO: 205587-50-4
• Molecular Weight: 296.366
• Mol File: 205587-50-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester(205587-50-4)
• EPA Substance Registry System: (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester(205587-50-4)

Safety Data

• Hazardous Substances Data: 205587-50-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 36438-64-9 p-benzyloxystyrene 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 40167-10-0 2-[4-(benzyloxy)phenyl]acetaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 22822-85-1 ethyl sodiodiethylphosphonoacetate 

Downstream Products

• 125251-66-3 Arbutamine hydrochloride 
• 205587-48-0 N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide 
• 205587-49-1 (R)-1-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[4-(4-methoxymethoxy-phenyl)-butylamino]-ethanol 
• 205587-51-5 4-(4-Methoxymethoxy-phenyl)-butyric acid ethyl ester 
• 205587-47-9 4-(4-Methoxymethoxy-phenyl)-butyric acid 
• 422321-76-4 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutanoate 
• 422321-74-2 4-(4'-benzyloxyphenyl)-1-bromobut-2-ene 
• 177959-34-1 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxy-1-p-toluenesulfonyloxybutane 
• 422321-77-5 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutan-1-ol 
• 177959-36-3 (2S,3S)-4-(4'-benzyloxyphenyl)-1,2-epoxy-3-hydroxybutane 
• 422321-75-3 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-dihydroxybutanoate 
• 422321-73-1 trans-4-(4-(benzyloxy)phenyl)-2-buten-1-ol 
• 62889-58-1 4-(4-hydroxyphenyl)butyric acid ethyl ester 

Relevant articles and documents

THIOARYL DERIVATIVES AS GPR120 AGONISTS

The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.

Catalytic asymmetric synthesis of arbutamine

An efficient catalytic asymmetric synthesis of (R)-arbutamine has been achieved using a catalytic asymmetric nitroaldol reaction promoted by a heterobimetallic multifunctional asymmetric catalyst as a key step.