205590-49-4

Basic information

• Product Name: (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid methyl ester
• CAS NO: 205590-49-4
• Molecular Weight: 695.923
• Mol File: 205590-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid methyl ester(205590-49-4)
• EPA Substance Registry System: (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid methyl ester(205590-49-4)

Safety Data

• Hazardous Substances Data: 205590-49-4(Hazardous Substances Data)

Upstream product

• 205590-47-2 (S)-2-(4-tert-Butoxycarbonylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester 
• 66493-39-8 4-(N-tert-butoxycarbonyl)aminobenzoic acid 
• 2666-93-5 (S)-Leu-OMe 
• 149910-63-4 N-α-(tert-butoxycarbonyl)-S-(triphenylmethyl)-L-cysteinal 

Relevant articles and documents

Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

In this paper we describe the synthesis of a family of CAAL peptidomimetics as GGTase-I inhibitors. These inhibitors lack the central dipeptide AA in the key CAAL carboxy terminal sequence of geranylgeranylated proteins and are more selective for GGTase-I over FTase. In whole cells, these compounds are very potent inhibitors of the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras. One derivative, GGTI-298, inhibited cell division by blocking cells in the G1 phase of the cell cycle.