20561-84-6Relevant articles and documents
Aldol type reaction of unprotected sugars in methanol
Saimoto, Hiroyuki,Yatani, Setsuo,Sashiwa, Hitoshi,Shigemasa, Yoshihiro
, p. 937 - 938 (1995)
Although aldol condensation of 1,3-dihydroxyacetone with formaldehyde in methanol catalyzed by CaCl2/KOH gave glycero-tetrulose, the reaction catalyzed by Ca(OH)2 preferentially gave 1,3-dihydroxyacetone dimer. The result was explained by the formation of a chelated enolate. This sequence was successfully applied to the stereoselective synthesis of threo-3-pentulose.
