205744-14-5

Basic information

• Product Name: (2-Chloropyridin-3-yl)methanamine
• Synonyms: RARECHEM AL BW 0316;(2-CHLORO-PYRIDIN-3-YL)-METHYLAMINE;3-Pyridinemethanamine,2-chloro-(9CI);3-AMINOMETHYL-2-CHLOROPYRIDINE;(2-Chloropyridin-3-yl)methanamine;C-(2-Chloro-pyridin-3-yl)-methylamine;2-chloro-3-PyridineMethanaMine;(2-chloro-3-pyridyl)methanamine
• CAS NO: 205744-14-5
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: HALIDE;PYRIDINE;Aminomethyl's;Pyridines
• Mol File: 205744-14-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 254.224 °C at 760 mmHg
• Flash Point: 107.551 °C
• Appearance: /
• Density: 1.244 g/cm³
• Vapor Pressure: 0.0175mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.30±0.29(Predicted)
• CAS DataBase Reference: (2-Chloropyridin-3-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloropyridin-3-yl)methanamine(205744-14-5)
• EPA Substance Registry System: (2-Chloropyridin-3-yl)methanamine(205744-14-5)

Safety Data

• Hazardous Substances Data: 205744-14-5(Hazardous Substances Data)

Usage

General Description

(2-Chloropyridin-3-yl)methanamine, also known as chloropyridine-3-ylmethanamine, is a chemical compound with the molecular formula C6H6ClN2. It is a derivative of pyridine and contains a chlorine atom in the 2-position and an amine group attached to the 3-position. (2-Chloropyridin-3-yl)methanamine is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential use as a ligand in coordination chemistry. The presence of the pyridine ring in the molecule provides unique reactivity and selectivity, making it a valuable intermediate in organic synthesis. Additionally, its diverse applications make it an important compound in the field of chemical research and development.

InChI:InChI=1/C6H7ClN2/c7-6-5(4-8)2-1-3-9-6/h1-3H,4,8H2

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 89581-84-0 2-chloro-3-(chloromethyl)pyridine 
• 500732-62-7 3-azidomethyl-2-chloro-pyridine 

Downstream Products

• 1258850-76-8 N-((2-chloropyridin-3-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)pyrazine-2-carboxamide 
• 1258268-93-7 C₁₈H₁₃Cl₂N₃O 
• 1420469-97-1 (2-Chloro-pyridin-3-ylmethyl)-[2-(3-hydroxymethyl-5-pyridin-2-ylmethyl-phenyl)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 1420469-38-0 [2-(3-benzyl-5-hydroxymethyl-phenyl)-2-oxo-ethyl]-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester 
• 1420470-01-4 N-[2-(3-benzylphenyl)-2-oxo-ethyl]-N-(2-chloro-pyridin-3-ylmethyl)-phenylsulfonamide 
• 422550-95-6 3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester 
• 422550-94-5 1-[3-benzyl-5-(1,1-dioxoisothiazolidin-2-ylmethyl)-phenyl]-1-(8-hydroxy-[1,6]naphthyridin-7-yl)-methanone 
• 500732-64-9 3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester 
• 500732-65-0 7-(3-benzyl-benzoyl)-8-oxo-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid benzyl ester 
• 500732-63-8 [2-(3-benzyl-phenyl)-2-oxo-ethyl]-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester 

Relevant articles and documents

Organic bifunctional catalyst and preparation method thereof as well as stereoregular biodegradable polyester and preparation method thereof

The invention relates to an organic bifunctional catalyst and a preparation method thereof, and stereoregular biodegradable polyester and a preparation method thereof. The organic bifunctional catalyst disclosed by the invention is obtained by reacting isocyanate or isothiocyanate with a pyridylamine compound. According to the catalyst, an O-carboxyl intracyclic anhydride monomer and a pyridine nucleophilic addition monomer of an amino acid source are activated by thiourea, and controllable ring opening polymerization can be performed on an OCA monomer under a mild condition by utilizing an amplification effect of adjacent groups, so that functional polyester with high isotacticity and controllable molecular weight is prepared. The solvent used for polymerization can be chloroform, toluene, dichloromethane and the like, the polymerization temperature range is 25-50 DEG C, and the stereoregularity is adjustable between 60% and 90%. Under the polymerization condition, the monomer conversion rate can reach 99% within 24-48 hours. The molecular weight of the obtained polyester is controllable, and the melting point reaches up to 150 DEG C. The molecular weight of the polyester is changed between 20,000 and 100,000, and the polyester has a wide prospect for industrial application.

Intramolecular N-arylation in heterocyclization: synthesis of new pyrido-fused pyrrolo[1,2-a][1,4]diazepinones

Alkylation of l-prolinamide with 3-(chloromethyl)-2-halopyridines, followed by cyclization through an intramolecular Pd-catalysed amidation, provided an entry to the pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10-one scaffold. Furthermore, a synthetic route towards diverse new pyrido[f]pyrrolo[1,2-a][1,4]diazepin-7-ones has been developed by acylation of contiguously substituted (aminomethyl)halopyridines with Boc-l-proline followed by intramolecular amination.

Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.