20601-38-1Relevant articles and documents
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Waldeland,Zartman,Adkins
, p. 4234,4236 (1933)
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Schaefgen,Flory
, p. 2823 (1948)
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Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439
Lau, Shing-Hing,Galván, Alicia,Merchant, Rohan R.,Battilocchio, Claudio,Souto, José A.,Berry, Malcolm B.,Ley, Steven V.
supporting information, p. 3218 - 3221 (2015/07/15)
An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that we
Efficient and Practical Arene Hydrogenation by Heterogeneous Catalysts under Mild Conditions
Maegawa, Tomohiro,Akashi, Akira,Yaguchi, Kiichiro,Iwasaki, Yohei,Shigetsura, Masahiro,Monguchi, Yasunari,Sajiki, Hironao
experimental part, p. 6953 - 6963 (2010/02/28)
An efficient and practical arene hydrogenation procedure based on the use of heterogeneous platinum group catalysts has been developed. Rh/C is the most effective catalyst for the hydrogenation of the aromatic ring, which can be conducted in iPrOH under neutral conditions and at ordinary to medium H 2 pressures (10 atm). A variety of arenes such as alkylbenzenes, benzoic acids, pyridines, furans, are hydrogenated to the corresponding cyclohexyl and heterocyclic compounds in good to excellet yields. The use of Ru/C, less expensive than Rh/C, affords an effective and practical method for the hydrogenation of arenes including phenols. Both catalysts can be reused several times after simple filtration without any significant loss of catalytic activity.