20615-18-3

Basic information

• Product Name: 4,4-DIMETHYLCYCLOHEXYLAMINE
• Synonyms: 4-AMINO-1,1-DIMETHYLCYCLOHEXANE;4,4-DIMETHYLCYCLOHEXYLAMINE;4,4-DIMETHYLCYCLOHEXANAMINE;4,4-diMethylcyclohexan-1-aMine;CyclohexanaMine,4,4-diMethyl-;CyclohexylaMine,4,4-diMethyl-
• CAS NO: 20615-18-3
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.23
• Mol File: 20615-18-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 160.5 °C at 760 mmHg
• Flash Point: 30.2 °C
• Appearance: /
• Density: 0.834 g/cm³
• Vapor Pressure: 2.38mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4,4-DIMETHYLCYCLOHEXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIMETHYLCYCLOHEXYLAMINE(20615-18-3)
• EPA Substance Registry System: 4,4-DIMETHYLCYCLOHEXYLAMINE(20615-18-3)

Safety Data

• Hazardous Substances Data: 20615-18-3(Hazardous Substances Data)

Usage

General Description

4,4-Dimethylcyclohexylamine is a chemical compound often used as an intermediate, catalyst, or additive in a number of chemical and industrial processes, including the production of pharmaceuticals, pesticides, rubber, resins, and polymers. It is a colorless to yellowish liquid that has a mild amine-like odor. Moreover, it can be a skin and eye irritant upon exposure. Its formula is C8H17N, and it's a secondary amine, which means it has two organic groups attached to the nitrogen atom. It also has the ability to accept protons due to the presence of a lone pair of electrons in nitrogen.

InChI:InChI=1/C8H17N/c1-8(2)5-3-7(9)4-6-8/h7H,3-6,9H2,1-2H3

Upstream product

• 4255-62-3 4,4-dimethylcyclohexane-1-one 
• 4701-96-6 4,4-dimethylcyclohexan-1-one oxime 

Downstream Products

• 1473450-60-0 NITD-304 
• 18289-06-0 C₂₈H₃₇N₃O₆S 
• 18289-05-9 C₂₆H₃₅N₃O₆S 
• 18192-91-1 C₂₅H₃₃N₃O₄S 
• 33021-79-3 N-<2-Fluor-aethyl>-N'-<4,4-dimethyl-cyclohexyl>-harnstoff 

Relevant articles and documents

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

Synthesis of potential anticancer agents. 38. N-Nitrosoureas. 4. Further synthesis and evaluation of haloethyl derivatives.

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