20633-93-6 Usage
Description
Fortunellin is a bioactive compound with potent anti-inflammatory properties, derived from natural sources. It specifically targets miR-374a, a negative regulator of the phosphatase and tensin homolog (PTEN), and has been shown to protect against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress through the AMPK/Nrf-2 pathway regulation.
Uses
Used in Pharmaceutical Applications:
Fortunellin is used as an anti-inflammatory agent for the treatment of inflammatory diseases. Its ability to target miR-374a and regulate the AMPK/Nrf-2 pathway makes it a promising candidate for the development of novel therapeutics to combat inflammation-related conditions.
Used in Cardiovascular Protection:
Fortunellin is used as a cardioprotective agent for the prevention and treatment of high fructose-induced diabetic heart injury. By suppressing inflammation and oxidative stress, Fortunellin can help mitigate the negative effects of diabetes on heart health.
Used in Antioxidant Formulations:
Fortunellin's potent antioxidant properties make it a valuable component in the development of antioxidant formulations. These formulations can be used in various applications, such as dietary supplements or skincare products, to promote overall health and well-being.
Used in Drug Delivery Systems:
Similar to gallotannin, Fortunellin can also be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By utilizing advanced drug delivery technologies, such as nanoparticles or liposomes, the efficacy of Fortunellin can be improved, allowing for more targeted and effective treatments for various conditions.
Biological Functions
Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.
Mechanism of action
Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.
Check Digit Verification of cas no
The CAS Registry Mumber 20633-93-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,6,3 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20633-93:
(7*2)+(6*0)+(5*6)+(4*3)+(3*3)+(2*9)+(1*3)=86
86 % 10 = 6
So 20633-93-6 is a valid CAS Registry Number.
InChI:InChI=1/C28H32O14/c1-11-21(32)23(34)25(36)27(38-11)42-26-24(35)22(33)19(10-29)41-28(26)39-14-7-15(30)20-16(31)9-17(40-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-9,11,19,21-30,32-36H,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
20633-93-6Relevant articles and documents
Synthesis of acacetin and resveratrol 3,5-di-O-β-glucopyranoside using lipase-catalyzed regioselective deacetylation of polyphenol glycoside peracetates as the key step
Hanamura, Shun,Hanaya, Kengo,Shoji, Mitsuru,Sugai, Takeshi
, p. 19 - 26 (2016)
Acacetin and resveratrol 3,5-di-O-β-glucopyranoside were synthesized from naturally abundant naringin and piceid in 65% and 62% overall yield, respectively. The key steps were the regioselective deacetylation of the peracetates of the glycosylated forms with Candida antarctica lipase B (Novozym 435) and Burkholderia cepacia lipase (Amano PS-IM). Deacetylation occurred exclusively at the least hindered position of the aromatic moieties and all acetyl groups in the sugar side chain remained intact. This excellent selectivity enabled regiospecific transformation of the liberated phenolic hydroxy groups, resulting in efficient synthesis of the target molecules.