20637-02-9

Basic information

• Product Name: 4-Nitrobenzenebutanoic acid methyl ester
• Synonyms: 4-(4-Nitrophenyl)butanoic acid methyl ester;4-Nitrobenzenebutanoic acid methyl ester;4-Nitrobenzenebutyric acid methyl ester
• CAS NO: 20637-02-9
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.2252
• Mol File: 20637-02-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 344.1°Cat760mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 6.74E-05mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Nitrobenzenebutanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrobenzenebutanoic acid methyl ester(20637-02-9)
• EPA Substance Registry System: 4-Nitrobenzenebutanoic acid methyl ester(20637-02-9)

Safety Data

• Hazardous Substances Data: 20637-02-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13NO4/c1-16-11(13)4-2-3-9-5-7-10(8-6-9)12(14)15/h5-8H,2-4H2,1H3

Upstream product

• 5600-62-4 4-(4-nitrophenyl)butanoic acid 
• 75-36-5 acetyl chloride 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 
• 1821-12-1 4-Phenylbutyric acid 
• 67857-97-0 4-(2-nitrophenyl)-n-butyric acid 

Downstream Products

• 20637-09-6 methyl 4-(4-aminophenyl)butanoate 
• 79481-83-7 methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 17981-81-6 chlorambucil chloride 
• 129787-13-9 3-[4-[N,N-bis(2-chloroethyl)amino]-phenyl]-propylamine 
• 90393-37-6 N,N-bis(2-chloroethyl)-4-(3-isocyanatopropyl)phenylamine 
• 130198-76-4 methyl 3-<4-phenyl>butyrate 
• 130031-42-4 Acridin-9-yl-(3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propyl)-amine 
• 305-03-3 chlorambucil 
• 1450984-23-2 C₂₂H₃₃NO₄ 
• 1146975-11-2 4-(4-((2-cyanopropan-2-yl)amino)phenyl)butanenitrile 
• 71825-33-7 4-[(4-amino)phenyl]butyrylnitrile 
• 22978-64-9 4-(4-nitro-phenyl)-butyronitrile 
• 1192366-93-0 N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide 
• 1192366-89-4 N-(3,4-dichlorophenethyl)-4-(4-(methylsulfonamido)-phenyl)butanamide 

Relevant articles and documents

Mass spectrometry of chlorambucil, its degradation products, and its metabolite in biological samples

A sensitive and specific method for the determination of chlorambucil and its metabolite in biological fluids is reported. The method is based on selected-ion monitoring detection following simple extraction of the parent compound, its metabolite, and an internal standard (chlorambucil-d8) from plasma and urine samples. The precision (reproducibility) of the method was 94.3 ± 1.3% with 200 ng of chlorambucil added to 1 ml of plasma. Chlorambucil degradation or alkylation of plasma proteins was minimal with plasma incubated at 24° for 4 hr. However, chlorambucil recovery decreased to 56% after plasma incubation at 37° for 4 hr. Three chlorambucil degradation products in ethyl acetate solution were found, and their structures were studied by mass spectrometry.

CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: -(CH2)1-4-, (C2-C4)-alkenyl, (C2-C4)alkynyl, -S-(CH2)1-3-#, and -(CH2)1-3-O-#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: -(CH2)2-4-, -S-(CH2)1-3#, and -O-(CH2)1-3-#,; where in the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: -OR4. The compounds of formula (I) are useful in the treatment of cancer

A new robust and versatile tetradentate linker for amides to be cleaved under mild conditions by unusual complexation of the amide nitrogen to Cu ++

The concept of weakening amide bonds by the rather unusual forced complexation of nitrogen to Cu++ is not limited to tridentate ligands and was extended in this work to tetradentate ligands as well. The use of cyclic tetradentate ligands was to no avail, but an open-chain and more-flexible tetradentate ligand allowed mild cleavage by methanolysis after complexation. The principle was applied to the development of a new linker for solid-phase chemistry, which was proven to be extremely robust, yet allowed mild cleavage after activation by Cu ++ complexation. Its stability and versatility was demonstrated by the successful application to a whole plethora of different types of reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009.