2065-27-2

Basic information

• Product Name: Methyl 2,6-dimethoxybenzoate
• Synonyms: RARECHEM AL BF 0201;METHYL 2,6-DIMETHOXYBENZOATE;2,6-DIMETHOXYBENZOIC ACID METHYL ESTER;METHYL 2,6-DIMETHOXYBENZATE;Methyl 2,6-dimethoxybenzoate 98%
• CAS NO: 2065-27-2
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• Product Categories: Aromatic Esters;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 2065-27-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 87-90 °C(lit.)
• Boiling Point: 294.9°Cat760mmHg
• Flash Point: 128°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2,6-dimethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-dimethoxybenzoate(2065-27-2)
• EPA Substance Registry System: Methyl 2,6-dimethoxybenzoate(2065-27-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2065-27-2(Hazardous Substances Data)

Usage

Uses

Methyl 2,6-dimethoxybenzoate may be employed as starting reagent in the total synthesis of (±)-hyperforin.

General Description

Methyl 2,6-dimethoxybenzoate is a useful inter-mediate for the synthesis of biologically active heterocyclic compounds. Its crystal structure has been investigated. Its molecule has a planar ester group which is at a dihedral angle of 81.46(3)° with respect to the benzene ring.

InChI:InChI=1/C10H12O4/c1-12-7-5-4-6-8(13-2)9(7)10(11)14-3/h4-6H,1-3H3

Upstream product

• 2150-45-0 methyl 2,6-dihydroxybenzoate 
• 74-88-4 methyl iodide 
• 32585-66-3 methyl 2,6-dimethoxybenzohydoxamate 
• 75-91-2 tert.-butylhydroperoxide 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 67-56-1 methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 151-10-0 1,3-Dimethoxybenzene 
• 201230-82-2 carbon monoxide 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 
• 144-55-8 sodium hydrogencarbonate 
• 16932-49-3 2,6-dimethoxybenzonitrile 
• 1445-45-0 Trimethyl orthoacetate 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 16929-70-7 1,3-dimethoxy-2-(1-hydroxy-1-methylethyl)benzene 
• 71819-90-4 2-(chloromethyl)-1,3-dimethoxybenzene 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 5673-07-4 2,6-dimethoxytoluene 
• 578-58-5 2-methylmethoxybenzene 
• 52159-62-3 2'-Hydroxy-6'-methoxy-2-(methylsulfinyl)acetophenon 
• 2734-70-5 2,6-dimethoxyaniline 
• 51410-99-2 2,6-dimethoxybenzohydroxamic acid 

Relevant articles and documents

Robust synthesis of NIR-emissive P-rhodamine fluorophores

P-Rhodamines were accessed by implementing a robust three step sequence consisting of (i) addition of m-metallated anilines to dichlorophosphine oxides, (ii) selective dibromination, and (iii) cyclization of the diaryllithium reagents derived from the dib

Electrochemical C-H cyanation of electron-rich (Hetero)arenes

A straightforward method for the electrochemical C-H cyanation of arenes and heteroarenes that proceeds at room temperature in MeOH, with NaCN as the reagent in a simple, open, undivided electrochemical cell is reported. The platinum electrodes are passivated by ad-sorbed cyanide, which allows conversion of an exceptionally broad range of electron-rich substrates all the way down to dialkyl arenes. The cyanide electrolyte can be replenished with HCN, opening opportunities for salt-free industrial C-H cyanation.

Nitrogen enriched mesoporous organic polymer anchored copper(ii) material: An efficient and reusable catalyst for the synthesis of esters and amides from aromatic systems

A new copper-grafted mesoporous poly-melamine-formaldehyde (Cu-mPMF) has been synthesized from melamine and paraformaldehyde in DMSO medium, followed by grafting of Cu(ii) at its surface. Cu-mPMF has been characterized by elemental analysis, powder XRD, HR TEM, FE-SEM, N2 adsorption study, FT-IR, UV-vis DRS, TGA-DTA, EPR spectroscopy, Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The Cu-grafted mesoporous material showed very good catalytic activity in methyl esterification of benzylic alcohols and amidation of nitriles. Moreover, the catalyst is easily recoverable and can be reused seven times without appreciable loss of catalytic activity in the above reactions. The highly dispersed and strongly bound Cu(ii) sites in the Cu-grafted mesoporous polymer could be responsible for the observed high activities of the Cu-mPMF catalyst. Due to strong binding with the functional groups of the polymer, no evidence of leached copper from the catalyst during the course of reaction emerged, suggesting true heterogeneity in the catalytic process. This journal is