206537-23-7

Basic information

• Product Name: N-(4-iodobenzyl)hydroxylamine
• Synonyms: N-(4-iodobenzyl)hydroxylamine
• CAS NO: 206537-23-7
• Molecular Weight: 249.051
• Mol File: 206537-23-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-iodobenzyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-iodobenzyl)hydroxylamine(206537-23-7)
• EPA Substance Registry System: N-(4-iodobenzyl)hydroxylamine(206537-23-7)

Safety Data

• Hazardous Substances Data: 206537-23-7(Hazardous Substances Data)

Upstream product

• 25895-60-7 sodium cyanoborohydride 
• 18282-51-4 4-iodo-benzyl alcohol 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 

Downstream Products

• 874347-06-5 C₁₀H₁₀INO₃ 
• 206537-24-8 C₉H₈INO₃ 

Relevant articles and documents

COMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS

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Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays

(-)-Shikimic acid, 3, was converted into both enantiomers of epoxycyclohexenol carboxylic acid, 7, which were attached to a solid support via a photocleavable linker. Tandem acylation-1,3-dipolar cycloaddition with nitrones 11a-g yielded tetracyclic templates 12a-g. After development of several efficient coupling reactions of iodobenzyl tetracycles 12b-d and completion of extensive validation protocols, a splitpool synthesis yielded a binary encoded library calculated to contain 2.18 million polycyclic compounds. These compounds are compatible with miniaturized cell-based 'forward' chemical genetic assays designed to explore biological pathways and 'reverse' chemical genetic assays designed to explore protein function. As a simple illustration of the potential of these compounds, several were shown to activate a TGF-β-responsive reporter gene in mammalian cells.