206559-19-5Relevant articles and documents
Syntheses of novel acyclic nucleosides, 9-(4′-hydroxy-2′-methylbut-1′-enyl) adenine and related compounds
Cheng, Changmei,Shimo, Tetsuro,Somekawa, Kenichi,Baba, Masanori
, p. 491 - 498 (2007/10/03)
An exploratory coupling reaction between adenine and a protected vicinal dibromo-intermediate was carried out to give the β,γ-unsaturated nucleoside analogues and a vinyl bromide derivative. Then a novel Cul catalytic coupling reaction between adenine and the vinyl bromide was successfully developed to afford an α,β-unsaturated acyclic nucleoside, 9-(4′-hydroxy-2′-methylbut-1′-enyl)adenine. All the above nucleosides were subjected to an anti-HIV-1 test.
