206559-72-0

Basic information

• Product Name: BETA-NITRO-4-(TRIFLUOROMETHOXY)STYRENE
• Synonyms: β-nitro-4-(trifluoromethoxy)styrene;1-(2-Nitroethenyl)-4-(trifluoromethoxy)benzene;1-(Trifluoromethoxy)-4-(2-nitrovinyl)benzene;4-(Trifluoromethoxy)(2-nitrovinyl)benzene;4-(Trifluoromethoxy)-1-(2-nitrovinyl)b;4-(Trifluoromethoxy)-beta-nitrostyrene
• CAS NO: 206559-72-0
• Molecular Formula: C₉H₆F₃NO₃
• Molecular Weight: 233.14
• Mol File: 206559-72-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 76-79 °C(lit.)
• Appearance: /
• CAS DataBase Reference: BETA-NITRO-4-(TRIFLUOROMETHOXY)STYRENE(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-NITRO-4-(TRIFLUOROMETHOXY)STYRENE(206559-72-0)
• EPA Substance Registry System: BETA-NITRO-4-(TRIFLUOROMETHOXY)STYRENE(206559-72-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 206559-72-0(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 1173094-17-1 ethyl 4-nitro-3-[4-(trifluoromethoxy)phenyl]-1H-pyrrole-2-carboxylate 
• 1374822-85-1 1-(2-nitro-1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazole 
• 1345832-03-2 (S)-tert-butyl 3-((R)-2-nitro-1-(4-(trifluoromethoxy)phenyl)ethyl)-2-oxo-3-(prop-2-ynyl)indoline-1- 

Relevant articles and documents

Squaramide-Linked Chloramphenicol Base Hybrid Catalysts for the Asymmetric Michael Addition of 2,3-Dihydrobenzofuran-2-carboxylates to Nitroolefins

An array of hybrid catalysts incorporating a chloramphenicol base moiety linked to another chiral scaffold through a squaramide linker were developed and successfully used in the Michael addition of 2,3-dihydrobenzofuran-2-carboxylates to nitroolefins. Control experiments suggested that the hybrid catalysts were more reactive than nonhybridized bifunctional catalysts, and matching of the chirality between the two scaffolds was crucial for high reactivity and stereoselectivity. These hybrid organocatalysts could be used with a variety of substrates. At a 0.5 mol-% catalyst loading, a range of 2,3-dihydrobenzofuran-2-carboxylates derivatives bearing quaternary and tertiary stereogenic centers were obtained in high yields (up to 98 %) with excellent enantioselectivities (up to 99 % ee) and moderate diastereoselectivities (up to 8:92 dr).

2,6-SUBSTITUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to a compound of formula (I) wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmaceutically acceptable salt, hydrate or solvate of the prodrug, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds of the invention in admixture with a pharmaceutically acceptable carrier, a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound of the invention.