206646-04-0 Usage
Description
Tenofovir Diphosphate is a bioactive metabolite of Tenofovir, a nucleotide reverse transcriptase inhibitor (NtRTI) used in the treatment of HIV and hepatitis B virus (HBV) infections. It is a white solid compound that contains an undetermined amount of water and phosphoric acid.
Uses
Used in Pharmaceutical Industry:
Tenofovir Diphosphate is used as an antiviral agent for the treatment of HIV and hepatitis B virus infections. It acts by inhibiting the activity of reverse transcriptase, a viral enzyme essential for the replication of these viruses, thereby suppressing their replication and reducing viral load in the body.
Used in Research Applications:
Tenofovir Diphosphate is also used as a research tool in the study of viral replication mechanisms, drug resistance, and the development of new antiviral therapies. Its unique chemical properties and activity against specific viral targets make it a valuable compound for understanding the molecular mechanisms of viral infections and the design of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 206646-04-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,6,4 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 206646-04:
(8*2)+(7*0)+(6*6)+(5*6)+(4*4)+(3*6)+(2*0)+(1*4)=120
120 % 10 = 0
So 206646-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H15N5O7P2/c1-6(20-5-22(15,16)21-23(17,18)19)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H,15,16)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1
206646-04-0Relevant articles and documents
Acyclic phosphonate nucleotides and human adenylate kinases: Impact of a borano group on α-P position
Topalis,Alvarez,Barral,Munier-Lehmann,Schneider,Veron,Guerreiro,Mulard,El-Amri,Canard,Deville-Bonne
, p. 319 - 331 (2008)
Adenylate kinases are involved in the activation of antiviral drugs such as the acyclic phosphonates analogs PMEA and (R)PMPA. We examine the in vitro phosphorylation of PMEA and PMPA bearing a borano- or a H- group on the phosphorus atom. The α-borano or α-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 1 and 2. Docking PMEA to the active site of AMP kinase 1 indicated that the borano group may prevent two conserved critical Arg interactions with the α-phosphate, resulting in substrate bad positioning. Copyright Taylor & Francis Group, LLC.