2068-89-5

Basic information

• Product Name: L-myo-Inositol-1,4,5-triphosphate (sodium salt)
• Synonyms: L-myo-Inositol-1,4,5-triphosphate (sodium salt);L-myo-Inositol-1,4,5-trisphosphate sodium salt;ZVCVTWVBDIPWPZ-FWMAINDVSA-K
• CAS NO: 2068-89-5
• Molecular Formula: C₆H₁₅O₁₅P₃
• Molecular Weight: 486.041073
• Mol File: 2068-89-5.mol
• Article Data: 37

Chemical Properties

• Appearance: White to off-white/Lyophilized Powder
• CAS DataBase Reference: L-myo-Inositol-1,4,5-triphosphate (sodium salt)(CAS DataBase Reference)
• NIST Chemistry Reference: L-myo-Inositol-1,4,5-triphosphate (sodium salt)(2068-89-5)
• EPA Substance Registry System: L-myo-Inositol-1,4,5-triphosphate (sodium salt)(2068-89-5)

Safety Data

• Hazardous Substances Data: 2068-89-5(Hazardous Substances Data)

Upstream product

• 104846-25-5 Phosphoric acid mono-((1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-phosphonooxy-cyclohexyl) ester 
• 120065-88-5 Benzoic acid (1R,2S,3R,4R,5S,6S)-2,5-bis-benzyloxy-3,4,6-tris-(bis-benzyloxy-phosphoryloxy)-cyclohexyl ester 
• 143366-69-2 1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate 
• 864372-86-1 2-O-acetyl-3,6-di-O-benzyl-1,4,5-tris-O-(3-oxo-1,5-dihydro-3λ⁵-2,4,3-benzodioxaphosphepin-3-yl)-D-myo-inositol 
• 120679-78-9 1D-2,3,6-O-tribenzoyl-myo-inositol 
• 119525-96-1 DL-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate) 
• 114342-70-0 Phosphoric acid dibenzyl ester (1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-(bis-benzyloxy-phosphoryloxy)-cyclohexyl ester 
• 114342-70-0 (+/-)-nona-O-benzyl-2,4,5-myo-inositol trisphosphate 
• 119525-96-1 L-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate) 
• 116839-49-7 (L)-4-O-benzyl-2,3-O-cyclohexylidene-myo-inositol 1,4,5-(hexabenzyl)trisphosphate 
• 124901-27-5 C₅₈H₆₄N₄O₁₇P₂ 
• 864373-02-4 2-O-acetyl-1,4-di-O-benzyl-3,5,6-tris-O-(3-oxo-1,5-dihydro-3λ⁵-2,4,3-benzodioxaphosphepin-3-yl)-D-myo-inositol 
• 864373-01-3 2-O-acetyl-1,4-di-O-benzyl-D-myo-inositol 
• 112212-81-4 (+/-)-(1S,2R,3R,4S)-1,4-diacetoxy-2,3-dibromocyclohex-5-ene 

Relevant articles and documents

Incorporation of a fluorous diazirine group into phosphatidylinositol 4,5-bisphosphate to illustrate its interaction with ADP-ribosylation factor 1

Phosphatidylinositides are one family of the most versatile signaling molecules in cells, yet how they interact with different proteins to regulate biological processes is not well understood. Towards a general strategy to identify phosphatidylinositide-protein interactions, a fluorous diazirine group has been incorporated into phosphatidylinositol 4,5-bisphosphate (PIP 2). The modified PIP2 was effectively cleaved by phospholipase C, one signaling protein that utilizes PIP2 as its endogenous substrate. Upon light illumination, the PIP2 probe effectively crosslinks with small GTPase ADP-ribosylation 1 to form a complex, suggesting that the probe might be suitable to identify PIP2- interacting proteins on the proteome level. The Royal Society of Chemistry 2012.

Synthesis of unsaturated phosphatidylinositol 4,5-bisphosphate and analogues

A new approach for the synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] is described, compatible with unsaturated fatty acid esters, as well as phosphorothioate and acetylenic analogues. This strategy depends on masking the ph

Divergent syntheses of all possible optically active regioisomers of myo-inositol tris- and tetrakisphosphates

Since the discovery of D-myo-inositol 1,4,5-trisphosphate, which plays a pivotal role as a second messenger in transmembrane signaling, the scope of the phosphoinositide-based signaling processes has been continually expanding. However, the clear understanding of the molecular signal transduction mechanisms including the functions of newly found IPn is still lacking. As a continuing effort to our previously reported syntheses of all possible 39 optically inactive regioisomers of myoinositol phosphates (IPn; n = 1-6), we synthesized all possible optically active regioisomers of myo-IP3 and myo-IP4 using chiral IBz3s and IBz2s, respectively. A series of procedures involving CRL-catalyzed enzymatic resolution of racemic 1,2:5,6-di-O-isopropylidene-myo-inositol and base-catalyzed benzoyl migration in tri- and dibenzoyl-isopropylidene-myo-inositol afforded eight enantiomeric pairs of IBz3 and six enantiomeric pairs of IBz2, respectively. Phosphorylation of these intermediates by the phosphitylation and oxidation procedure gave the target products.