20705-59-3 Usage
Description
4-Tetrahydropyranyloxy-butan-2-one 90%, also known as THP-protected butan-2-one, is a colorless oil compound that is commonly used in organic synthesis. It is characterized by its tetrahydropyranyl (THP) protecting group, which is used to protect the carbonyl group of the butan-2-one molecule. This protecting group can be selectively removed under mild acidic conditions, making it a versatile intermediate in the synthesis of various organic compounds.
Uses
Used in Organic Synthesis:
4-Tetrahydropyranyloxy-butan-2-one 90% is used as a protecting group in organic synthesis for the carbonyl group of butan-2-one. The THP group can be selectively removed under mild acidic conditions, allowing for the controlled synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Tetrahydropyranyloxy-butan-2-one 90% is used as an intermediate in the synthesis of various drug molecules. The THP protecting group allows for the selective protection and deprotection of the carbonyl group, enabling the synthesis of complex drug candidates with multiple functional groups.
Used in Flavor and Fragrance Industry:
4-Tetrahydropyranyloxy-butan-2-one 90% is also used in the flavor and fragrance industry as a building block for the synthesis of various aroma chemicals. The THP protecting group allows for the selective modification of the butan-2-one core, enabling the creation of novel fragrance compounds with unique scent profiles.
Used in Material Science:
In material science, 4-Tetrahydropyranyloxy-butan-2-one 90% can be used as a precursor for the synthesis of novel polymers and materials with specific properties. The THP protecting group allows for the controlled synthesis of polymers with tailored chemical and physical properties, such as solubility, stability, and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 20705-59-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,7,0 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 20705-59:
(7*2)+(6*0)+(5*7)+(4*0)+(3*5)+(2*5)+(1*9)=83
83 % 10 = 3
So 20705-59-3 is a valid CAS Registry Number.
20705-59-3Relevant articles and documents
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Tatematsu et al.
, p. 205,212 (1968)
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A Method for the Late-Stage Formation of Ketones, Acyloins, and Aldols from Alkenylstannanes: Application to the Total Synthesis of Paecilonic Acid A
Sommer, Heiko,Hamilton, James Y.,Fürstner, Alois
, p. 6161 - 6165 (2017/05/22)
Treatment of alkenylstannanes with Cu(OAc)2/Et3N affords the corresponding enol esters or ketones under conditions that proved compatible with many common functionalities; these include groups that would neither survive under the sta
Synthesis of natural maleimides farinomaleins C-E and evaluation of their antifungal activity
Lahore, Santosh,Aiwale, Sachin T.,Sardi, Paola,Dallavalle, Sabrina
, p. 4196 - 4198 (2014/07/22)
A practical and convenient synthesis of naturally occurring farinomaleins C-E was achieved starting from readily available ethyl 3-methyl-2-oxobutyrate and triethyl phosphonoacetate. The key steps of the sequence included a Horner-Wadsworth-Emmons condensation to obtain the precursor farinomalein A and coupling with suitable alcohols to install the chain. The synthesis of farinomalein D has been achieved starting from (R)-isopropylideneglycerol on the basis of which the S configuration was assigned to the natural compound. The antifungal activity of the synthesized compounds was evaluated against Cladosporium cladosporioides.
