207112-22-9

Basic information

• Product Name: 5-{N-[4-(4'-chlorophenoxy)but-2-ynyl]-N-ethylamino}-1,3-dimethyluracil
• Synonyms: 5-{N-[4-(4'-chlorophenoxy)but-2-ynyl]-N-ethylamino}-1,3-dimethyluracil
• CAS NO: 207112-22-9
• Molecular Weight: 361.828
• Mol File: 207112-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{N-[4-(4'-chlorophenoxy)but-2-ynyl]-N-ethylamino}-1,3-dimethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{N-[4-(4'-chlorophenoxy)but-2-ynyl]-N-ethylamino}-1,3-dimethyluracil(207112-22-9)
• EPA Substance Registry System: 5-{N-[4-(4'-chlorophenoxy)but-2-ynyl]-N-ethylamino}-1,3-dimethyluracil(207112-22-9)

Safety Data

• Hazardous Substances Data: 207112-22-9(Hazardous Substances Data)

Upstream product

• 7033-39-8 5-bromo-1,3-dimethyluracil 
• 4200-22-0 1-(4-chlorophenyl)oxy-4-chloro-but-2-yne 
• 207112-20-7 5-(ethylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 207112-28-5 3-Chloro-benzoic acid 6-(4-chloro-phenoxymethyl)-5-ethyl-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl ester 

Relevant articles and documents

Studies on Pyrimidine-Annelated Heterocycles: Synthesis of Pyrrolo[3,2-d]pyrimidines by Amine Oxide Rearrangement

A number of pyrrolo[3,2-d]pyrimidine derivatives (5a-f) were synthesized in 90-95% yields from the corresponding 5-[N-[4-(aryloxy)but-2-ynyl]-N-ethylamino]-1,3-dimethyluracils 4a-f by simple treatment with 1 equiv of m-chloroperoxybenzoic acid in dichloromethane at 0-5 °C for 12-15 h. The resulting benzoates (5a-f) were easily converted to methoxy derivatives 11a-f in 92-94% yields when refluxed in methanol for 20-22 h.