20719-68-0

Basic information

• Product Name: Isopropylamine, 2-(methoxymethyl)-
• Synonyms: Isopropylamine, 2-(methoxymethyl)-;2-Methyl-3-methoxypropan-2-amine;1-Methoxy-2-amino-2-methylpropane;Brn 2423799;Isopropylamine, 1-methoxy-2-methyl-;tert-Butylamine, 1-methoxy-;(2-methoxy-1,1-dimethylethyl)amine(SALTDATA: HCl);(2-Methoxy-1,1-dimethylethyl)amine
• CAS NO: 20719-68-0
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16
• Mol File: 20719-68-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 119.7 °C at 760 mmHg
• Flash Point: 23.2 °C
• Appearance: /
• Density: 0.851 g/cm³
• Vapor Pressure: 15.8mmHg at 25°C
• Refractive Index: 1.416
• CAS DataBase Reference: Isopropylamine, 2-(methoxymethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropylamine, 2-(methoxymethyl)-(20719-68-0)
• EPA Substance Registry System: Isopropylamine, 2-(methoxymethyl)-(20719-68-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20719-68-0(Hazardous Substances Data)

Usage

General Description

Isopropylamine, 2-(methoxymethyl)- is a chemical compound with the formula C5H13NO. It belongs to the group of amines, which are organic compounds derived from ammonia. This particular compound consists of an isopropylamine group and a methoxymethyl group. Isopropylamine, 2-(methoxymethyl)- is commonly used in the pharmaceutical and chemical industries as a reagent or intermediate for the synthesis of various organic compounds. It is also used in the production of pesticides, dyes, and other industrial chemicals. Due to its versatile nature and utility, this compound is considered an important building block for the synthesis of numerous chemicals and pharmaceuticals.

InChI:InChI=1/C5H13NO/c1-5(2,6)4-7-3/h4,6H2,1-3H3

Upstream product

• 204707-34-6 tert-butyl (1-methoxy-2-methylpropan-2-yl)carbamate 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 74-88-4 methyl iodide 
• 2658-24-4 2,2-dimethylaziridine 
• 67-56-1 methanol 

Downstream Products

• 2951-54-4 Toluol-4-sulfonsaeure-<β-methoxy-tert.-butylamid> 
• 1443156-96-4 C₁₉H₃₃NO₂Si 
• 1443157-01-4 C₁₂H₁₇NO₂ 
• 1443156-94-2 C₁₆H₂₅NO₂ 
• 1415149-79-9 C₂₁H₂₂F₄N₂O₄S 
• 1415149-75-5 C₂₁H₂₃F₃N₂O₄S 
• 1415149-77-7 C₂₁H₂₃F₃N₂O₅S 
• 1253787-20-0 N₂-[1,1-dimethyl-2-(methoxy)ethyl]-3-iodo-N₁-[4-cyano-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide 
• 1253787-18-6 N₂-[1,1-dimethyl-2-(methoxy)ethyl]-3-iodo-N₁-[4-chloro-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide 
• 1253787-17-5 N₂-[1,1-dimethyl-2-(methoxy)ethyl]-3-iodo-N₁-[3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide 
• 1236150-05-2 N-(1,1-dimethyl-2-methoxyethyl)-3-iodophthalamic acid 

Relevant articles and documents

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Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Mechanism of Helix Induction on a Stereoregular Poly((4-carboxyphenyl)acetylene) with Chiral Amines and Memory of the Macromolecular Helicity Assisted by Interaction with Achiral Amines

Cis-transoidal poly((4-carboxyphenyl)acetylene) (poly-1) is an optically inactive polymer but forms an induced one-handed helical structure upon complexation with optically active amines such as (R)-(1-(1-naphthyl)ethyl) amine ((R)-2) in DMSO. The complexes show a characteristic induced circular dichroism (ICD) in the UV-visible region of the polymer backbone. Moreover, the macromolecular helicity of poly-1 induced by (R)-2 can be "memorized" even after complete replacement of (R)-2 by various achiral amines. We now report fully detailed studies on the mechanism of the helicity induction and memory of the helical chirality of poly-1 by means of UV-visible, CD, and infrared spectroscopies. We have found that a one-handed helix is cooperatively induced on poly-1 upon the ion pair formation of the carboxy groups of poly-1 with optically active amines and that the bulkiness of the chiral amines plays a crucial role for inducing an excess of a single-handed helix. On the other hand, the free ion formation was found to be essential for the macromolecular helicity memory of poly-1 after the replacement of the chiral amine by achiral amines, since the intramolecular electrostatic repulsion between the neighboring carboxylate ions of poly-1 significantly contributes to reduce the atropisomerization process of poly-1. On the basis of the mechanism of helicity induction and the memory of the helical chirality drawn from the present studies, we succeeded in creating an almost perfect memory of the induced macromolecular helicity of poly-1 with (R)-2 by using 2-aminoethanol as an achiral chaperoning molecule to assist in maintaining the memory of helical chirality.