207296-87-5

Basic information

• Product Name: 1H-Indazole-3-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-
• CAS NO: 207296-87-5
• Molecular Formula: C20H22N4O
• Molecular Weight: 334.421
• Mol File: 207296-87-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Indazole-3-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-3-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-(207296-87-5)
• EPA Substance Registry System: 1H-Indazole-3-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-(207296-87-5)

Safety Data

• Hazardous Substances Data: 207296-87-5(Hazardous Substances Data)

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 4498-67-3 1H-Indazole-3-carboxylic acid 

Relevant articles and documents

5-HTX MODULATORS

This invention relates to compounds which bind to serotonin receptors inside or outside the central nervous system, in particular compounds which bind to the 5-HT2 or 5-HT7 receptors, their preparation and use, compositions containing them, and methods of treatment using them.

5-HT4 agonists and antagonists

Compounds of formula I: are used as antagonists and partial agonists for the serotonin receptor 5-HT4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT4 receptor.

Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone derivatives

A series of indole-3-carboxamides, indazole-3-carboxamides, and benzimidazolone-3-carboxamides was synthesized and evaluated for antagonist affinity at the 5-HT4 receptor in the rat esophagus. The endo-3-tropanamine derivatives in the indazole