2074-53-5 Usage
Description
Vitamin E, also known as tocopherol, is a fat-soluble vitamin that plays a crucial role in various biological functions. It is a powerful antioxidant and free radical scavenger, which helps protect cells from oxidative damage. Vitamin E is essential for maintaining healthy skin, supporting the immune system, and promoting overall well-being.
Uses
Used in Skin Care:
Vitamin E is used as an antioxidant and moisturizer in the skin care industry. It helps protect the skin from free radical damage, enhances blood circulation, and improves the skin's water-binding ability. Vitamin E is also effective in reducing transepidermal water loss, which contributes to the improvement of rough, dry, and damaged skin. Additionally, it is believed to have anti-inflammatory properties and can help prevent irritation caused by sun exposure.
Used in Cosmetic Formulations:
Vitamin E is used as a preservative and moisturizer in cosmetic formulations. Its antioxidant properties help protect the product from oxidation, increasing its longevity. It is also useful in anti-aging creams and lotions, as well as UV protective products. Vitamin E can be found naturally in various cereal germ oils, such as wheat germ oil, or can be produced synthetically.
Used in Pharmaceutical Applications:
Vitamin E, under the brand names Aquasol E (Astra), Eprolin (Lilly), and Natopherol (Abbott), is used as a supplement in the pharmaceutical industry. It has demonstrated success in the treatment of yellow nail syndrome when taken orally or applied topically, leading to significant improvement in symptoms and increased nail growth rates.
Used in the Food Industry:
Vitamin E is used as a preservative to protect against oxidation, benefiting not only the food itself but also its shelf life. It is commonly added to various food products to maintain their freshness and quality.
Indications
Vitamin E is a potent antioxidant that is capable of protecting
polyunsaturated fatty acids from oxidative
breakdown.This vitamin also functions to enhance vitamin
A use.Although several other physiological actions
have been suggested, to date no unifying concept exists
to explain these actions. Vitamin E (α-tocopherol) is
found in a variety of foodstuffs, the richest sources being
plant oils, including wheat germ and rice, and the
lipids of green leaves.
Clinical Use
Deficiency of vitamin E is characterized by low
serum tocopherol levels and a positive hydrogen peroxide
hemolysis test.This deficiency is believed to occur in
patients with biliary, pancreatic, or intestinal disease
that is characterized by excessive steatorrhea. Premature
infants with a high intake of fatty acids exhibit a
deficiency syndrome characterized by edema, anemia,
and low tocopherol levels.This condition is reversed by
giving vitamin E.
Side effects
Prolonged administration of large dosages of vitamin
E may result in muscle weakness, fatigue, headache,
and nausea.This toxicity can be reversed by discontinuing
the large-dose supplementation.
Toxicology
α-Tocopherol is known as vitamin E and exists in many kind of plants, especially in lettuce and alfalfa. Its color changes from yellow to dark brown when exposed to sunlight. Natural vegetable oils are not readily oxidized due to the presence of
tocopherol. During refining processes, however, tocopherol may be removed
from oils; consequently, refined vegetable oils can become unstable toward
oxidation. In one experiment, vitamin E appeared to be relatively innocuous,
having been given to patients for months both orally and parenterally
at a dosage level of 300 mg/day without any observed ill effects. However,
in another experiment, 6 out of 13 patients given similar doses complained
of headache, nausea, fatigue, dizziness, and blurred vision.
Although the chronic toxicity of vitamin E has not been thoroughly
studied, WHO recommends 2 mg/kg/day as the maximum daily dose.
Check Digit Verification of cas no
The CAS Registry Mumber 2074-53-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,7 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2074-53:
(6*2)+(5*0)+(4*7)+(3*4)+(2*5)+(1*3)=65
65 % 10 = 5
So 2074-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
2074-53-5Relevant articles and documents
Process of separating chiral isomers of chroman compounds and their derivatives and precursors
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Page/Page column 14, (2012/12/13)
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.
Electron Transfer Reactions of Halothane-derived Peroxyl Free Radicals, CF3CHClO2.: Measurement of Absolute Rate Constants by Pulse Radiolysis
Moenig, Joerg,Asmus, Klaus-Dieter,Schaeffer, Michel,Slater, Trevor F.,Willson, Robin L.
, p. 1133 - 1138 (2007/10/02)
The halothane-derived peroxyl radical CF3CHClO2. has been generated in aqueous solutions by pulse radiolysis.Absolute rate constants for the reduction of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hydrated electrons, hydrogen atoms, and propan-2-ol free radicals have been determined to be k 1.4E10, 3.8E8, and 7.6E7 l mol-1 s-1, respectively.The predominant product radical CF3CHCl rapidly adds O2, and an estimate of k 1.3E9 l mol-1 s-1, has been obtained for the absolute rate constant of this reaction.The resulting peroxyl radical CF3CHClO2. has been found to react rapidly with a variety of nucleophilic compounds such as 2,2'-azinobis(3-ethylbenzthiazoline-6-sulphonate), the phenothiazines promethazine, chlorpromazine, and metiazinic acid, the vitamins C and E, and propyl gallate.The absolute rate constants for these reactions are found to be generally lower than for corresponding reactions of the carbon tetrachloride-derived radical, CCl3O2..
