20752-48-1

Basic information

• Product Name: (+)-(S)(C)-(S)(S)-N-(1-Phenylethyl)-p-toluolsulfinamid
• Synonyms: (+)-(S)(C)-(S)(S)-N-(1-Phenylethyl)-p-toluolsulfinamid
• CAS NO: 20752-48-1
• Molecular Weight: 259.372
• Mol File: 20752-48-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(S)(C)-(S)(S)-N-(1-Phenylethyl)-p-toluolsulfinamid(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(S)(C)-(S)(S)-N-(1-Phenylethyl)-p-toluolsulfinamid(20752-48-1)
• EPA Substance Registry System: (+)-(S)(C)-(S)(S)-N-(1-Phenylethyl)-p-toluolsulfinamid(20752-48-1)

Safety Data

• Hazardous Substances Data: 20752-48-1(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 188447-91-8 (S)-p-toluenesulfinimide 
• 100-47-0 benzonitrile 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 
• 220732-34-3 (S)-(E)-N-ethylidene-4-methylbenzenesulfinamide 
• 75-16-1 methylmagnesium bromide 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 866993-20-6 (S)-4-methyl-N-(1-phenylethylidene)benzenesulfinamide 
• 65440-68-8 [S-(E)]-(+)-N-α-methylbenzylidene-p-toluenesulfinamide 

Downstream Products

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 64396-66-3 methyl (R)-4-methylbenzenesulfinate 
• 72984-27-1 4-Methyl-N-((R)-1-phenyl-ethyl)-benzenesulfonamide 
• 66558-04-1 N-[(1S)-1-phenylethan-1-yl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Rare-Earth-Catalyzed Transsulfinamidation of Sulfinamides with Amines

A rare-earth-catalyzed transsulfinamidation of primary sulfinamides with alkyl, aryl, and heterocyclic amines for the synthesis of diverse secondary and tertiary sulfinamides has been realized. Unlike transition metal-catalyzed cross-coupling approaches restricted to non-commercially available disubstituted O-benzoyl hydroxylamines, this newly developed protocol is suitable for diverse readily available primary and secondary amines without any modifications. Excellent catalytic activity and selectivity are achieved with Eu(OTf)3 under mild reaction conditions, which extends the applicability of rare-earth catalysis.

Stereoselective Addition Reactions of Chiral N-Benzylidene-p-toluenesulfinamides. Asymmetric Syntheses of β- and γ-Amino Acids

Chiral N-benzylidene-p-toluenesulfinamides 2 were prepared by the reaction of benzonitril with alkyllithium in ether followed by (-)-l-menthyl (S)-p-tolylsulfinate.Treatment of 2 with allylmagnesium bromide in ether at 0 deg C gave the adducts (R)-7 with excellent stereoselectivity.Pure chiral sulfinamides 7 were converted into β- and γ-amino acids in four and five steps, respectively.