2076-91-7

Basic information

• Product Name: NSC 55712
• Synonyms: NSC 55712;TPT-260 (Dihydrochloride);TPT-260 (Dihydrochloride), NSC55712;TPT-260 2HCl;Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride;TPT-260 , NSC55712;NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride;TPT-260 Dihydrochloride, >=98%
• CAS NO: 2076-91-7
• Molecular Formula: C8H14Cl2N4S3
• Molecular Weight: 333.32456
• Product Categories: Inhibitors
• Mol File: 2076-91-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 210℃ (Decomposition)
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: NSC 55712(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 55712(2076-91-7)
• EPA Substance Registry System: NSC 55712(2076-91-7)

Safety Data

• Hazardous Substances Data: 2076-91-7(Hazardous Substances Data)

Usage

Description

NSC 55712, also known as TPT-260, is a thiophene thiourea derivative that functions as a chaperone to stabilize the retromer complex against thermal denaturation. It plays a crucial role in preventing the formation of Alzheimer's disease-inducing fragments by redirecting the amyloid-precursor protein (APP) away from the endosome.
Used in Pharmaceutical Industry:
NSC 55712 is used as a stabilizing agent for the retromer complex to prevent the formation of Alzheimer's disease-inducing fragments. It helps in stabilizing the retromer complex against thermal denaturation and redirects APP from the endosome, reducing the formation of pathogenic APP.
Used in Neuroprotection:
NSC 55712 is used as a neuroprotective agent to prevent the cleavage of APP into Alzheimer's disease-inducing fragments. By increasing the level of retromer proteins in cultured hippocampal neurons, it helps in protecting the neurons from the harmful effects of Alzheimer's disease.
Used in Drug Development:
NSC 55712 is used as a potential therapeutic agent in the development of drugs targeting Alzheimer's disease. Its ability to stabilize the retromer complex and redirect APP from the endosome makes it a promising candidate for further research and development in the treatment of neurodegenerative diseases.