207680-03-3

Basic information

• Product Name: 10-O-benzoyl-10-deacetylbaccatin III
• Synonyms: 10-O-benzoyl-10-deacetylbaccatin III
• CAS NO: 207680-03-3
• Molecular Weight: 648.707
• Mol File: 207680-03-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 10-O-benzoyl-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 10-O-benzoyl-10-deacetylbaccatin III(207680-03-3)
• EPA Substance Registry System: 10-O-benzoyl-10-deacetylbaccatin III(207680-03-3)

Safety Data

• Hazardous Substances Data: 207680-03-3(Hazardous Substances Data)

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 709633-36-3 C₅₈H₆₆N₄O₁₄Si 
• 709633-37-4 C₅₈H₆₆ClNO₁₄Si 
• 709633-23-8 C₄₈H₆₇N₃O₁₁Si₂ 
• 709633-19-2 C₄₈H₆₇ClO₁₁Si₂ 
• 566899-46-5 2-debenzoyl-2-m-azidobenzoyl-10-deacetyl-10-benzoyl-7-triethylsilylbaccatin III 
• 566899-47-6 2-debenzoyl-2-m-chlorobenzoyl-10-deacetyl-10-benzoyl-7-triethylsilylbaccatin III 
• 709633-15-8 C₄₁H₆₄O₁₀Si₂ 
• 566899-38-5 2-debenzoyl-2-m-azidobenzoyl-10-deacetyl-10-benzoylbaccatin III 
• 566899-39-6 2-debenzoyl-2-m-chlorobenzoyl-10-deacetyl-10-benzoylbaccatin III 
• 709633-06-7 C₄₈H₆₈O₁₁Si₂ 

Relevant articles and documents

Organocatalytic site-selective acylation of 10-deacetylbaccatin III

Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.

Lanthanide trifluoromethanesulfonate catalysed selective acylation of 10-deacetylbaccatin III

The selective C-10 acylation of 10-deacetylbaccatin III to baccatin III and derivatives is very efficiently catalysed by lanthanide trifluoromethanesulfonates. Baccatin III, now readily available through this procedure, is an important precursor for an economically viable semisynthesis of paclitaxel and its derivatives.