2078-01-5Relevant articles and documents
Glycine receptor antagonists and the use thereof
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, (2008/06/13)
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.
19F NMR as an Analytical Tool for Fluorinated Agrochemical Research
Mabury, Scott A.,Crosby, Donald G.
, p. 1845 - 1848 (2007/10/03)
19F NMR was utilized to monitor the photodegradation of trifluralin directly in NMR tubes without extraction, cleanup, concentration, or chromatographic separation.Dissipation curves were generated for the parent pesticide and degradation products, and the major products identified by addition of authentic standarts were α-α-α-trifluoro-2,6-dinitro-N-propyl-p-toluidine (II), α,α,α-trifluoro-2,6-dinitro-p-toluidine (III), and 2-ethyl-7-nitro-5-(trifluoromethyl)benzimidazole (VII).Numerous peaks were observed in the spectra that may represent labile intermediates not generally observed with other analytical techniques.Keywords: 19F NMR; trifluralin; photodegradation
Control of animal parasites with benzimidazoles
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, (2008/06/13)
A class of substituted benzimidazoles are useful parasiticides for the systemic control of insects and acarina which feed on living tissues of animals. The compounds, which control both bloodsucking parasites and flesh-eating parasites, are characterized