20785-46-0

Basic information

• Product Name: 1-allyltetrahydro-4(1H)-pyridinone
• Synonyms: 1-allyltetrahydro-4(1H)-pyridinone;1-(2-propen-1-yl)-4-Piperidinone
• CAS NO: 20785-46-0
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.19
• Mol File: 20785-46-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 218.1 °C at 760 mmHg
• Flash Point: 79.5 °C
• Appearance: /
• Density: 0.972 g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: 1-allyltetrahydro-4(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-allyltetrahydro-4(1H)-pyridinone(20785-46-0)
• EPA Substance Registry System: 1-allyltetrahydro-4(1H)-pyridinone(20785-46-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 20785-46-0(Hazardous Substances Data)

Usage

General Description

1-Allyltetrahydro-4(1H)-pyridinone is a chemical compound with the molecular formula C9H15NO. It is a derivative of tetrahydropyridinone and contains an allyl group attached to the nitrogen atom. 1-Allyltetrahydro-4(1H)-pyridinone is commonly used in organic synthesis as a versatile building block for various chemical reactions. It has been studied for its potential biological activities, including its anti-inflammatory and analgesic properties. 1-Allyltetrahydro-4(1H)-pyridinone is also known for its role as a chiral auxiliary in asymmetric synthesis, making it a valuable tool in the production of enantiomerically pure compounds. Overall, this compound plays a significant role in the field of organic chemistry and has potential applications in the development of pharmaceuticals and other fine chemicals.

InChI:InChI=1/C8H13NO/c1-2-5-9-6-3-8(10)4-7-9/h2H,1,3-7H2

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 107-05-1 3-chloroprop-1-ene 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 79508-92-2 N-allyl-4-piperidinol 
• 4046-08-6 Bis(carbethoxyethyl)allylamine 
• 148254-43-7 1-allyl-4-oxo-piperidine-3-carboxylic acid ethyl ester 

Downstream Products

• 86147-32-2 1-allyl-4-phenylpiperidin-4-ol 
• 14749-63-4 1-allyl-4-phenyl-4-propionyloxy-piperidine 

Relevant articles and documents

Convenient synthesis of 3,7-diazabicyclo[3.3.1]nonane (bispidine)

Bispidine 1a is conveniently synthesized via a route involving double Mannich reaction of 1-allylpiperidin-4-one to N,N′-diallylbispidinone, Wolff-Kishner reduction of the bispidinone, and deallylation of the resulting N,N′-diallylbispidine by treatment with ethyl chloroformate in the presence of NaI, followed by alkaline hydrolysis.

Highly chemoselective aerobic oxidation of amino alcohols into amino carbonyl compounds

The direct oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has often posed serious challenges in organic synthesis and has constrained chemists to adopting an indirect route, such as a protection/deprotection strategy, to attain their goal. Described herein is a highly chemoselective aerobic oxidation of unprotected amino alcohols to their amino carbonyl compounds in which 2-azaadamantane N-oxyl (AZADO)/copper catalysis is used. The catalytic system developed leads to the alcohol-selective oxidation of various unprotected amino alcohols, carrying a primary, secondary, or tertiary amino group, in good to high yield at ambient temperature with exposure to air, thus offering flexibility in the synthesis of nitrogen-containing compounds. Strong as an ox: The highly chemoselective aerobic oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has been achieved by using 2-azaadamantane N-oxyl (AZADO)/copper catalysis. This catalytic system oxidizes not only alcohols with tertiary amino groups but also those with secondary and primary amines in good to high yield at ambient temperature in air. bpy=2,2-bipyridyl, DMAP=4-(N,N-dimethylamino)pyridine.