208167-83-3

Basic information

• Product Name: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
• Synonyms: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt;N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE;tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate;N-BOC-Nzzhlxy-(2-Chloroethyl)piperazine hydrochloride;1-Boc-4-(2-chloroethyl)piperazine, 97%;tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(2-chloroethyl)piperazine;2-(benzyloxy)-5-fluorobenzaldehydetert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate;4-(2-Chloroethyl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 208167-83-3
• Molecular Formula: C₁₁H₂₁ClN₂O₂
• Molecular Weight: 248.76
• Mol File: 208167-83-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 67-69°C
• Boiling Point: 318.4°C at 760 mmHg
• Flash Point: 146.4°C
• Appearance: White to light brown/Crystalline Powder
• Density: 1.106g/cm³
• Vapor Pressure: 0.000362mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: Slightly Soluble (7.2 g/L) (25°C).
• PKA: 6.13±0.10(Predicted)
• CAS DataBase Reference: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt(208167-83-3)
• EPA Substance Registry System: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt(208167-83-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 208167-83-3(Hazardous Substances Data)

Usage

Description

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is a chemical compound that features a piperazine core with a chloroethyl group and a Boc-protecting group. It is a versatile intermediate in organic synthesis and has potential applications in the development of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its chloroethyl moiety can be utilized in the synthesis of nitrogen mustards, which are known for their anticancer properties.
Used in Anticancer Research:
In a study of anticancer activity of dihydroxyanthrathiazolediones, N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used as a key component in the synthesis of these compounds. The dihydroxyanthrathiazolediones have shown promising anticancer activity, making this compound an important part of ongoing research in cancer treatment.
Used in the Synthesis of BEL-7404 Liver Cancer Cells:
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used in the direct condensation of chloroalkyl piperazine, nitrogen mustard benzaldehyde, and pyrrole to produce BEL-7404 liver cancer cells. N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt has demonstrated anticancer activity, making it a valuable tool in the development of new cancer therapies.

InChI:InChI=1/C11H21ClN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3

Upstream product

• 61308-25-6 Chloroethylpiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 107-04-0 1-Bromo-2-chloroethane 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 77279-24-4 tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate 

Downstream Products

• 59955-93-0 N-isopropyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine 
• 3644-18-6 N-(2-(dimethylamino)ethyl)piperazine 
• 4892-89-1 4-(2-(piperazin-1-yl)ethyl)morpholine 
• 22763-65-1 4-[2-(piperidin-1-yl)ethyl]piperazine 
• 4038-92-0 4-[2-(diethylamino)ethyl]piperazine 
• 22763-69-5 4-[2-(1-pyrrolidinyl)ethyl]piperazine 

Relevant articles and documents

Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents

Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11- dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro.

N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES

The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Compound and application of compound to treating colon cancer

The invention discloses a compound and application of the compound to treating the colon cancer. The structural formula of the compound is shown in the formula I, wherein R1, R2, R3 and R4 in the formula I are respectively independently chosen from alkyl groups and alkoxy groups, the number of hydrogen atoms, halogen, nitro and carbon atoms in the alkyl group is 1-6, the number of carbon atoms in the alkoxy group is 1-6, R5 is chosen from nitro and -NR6R7, wherein R6 and R7 are respectively independently the hydrogen atom or CH2Ar, the Ar represents a phenyl group or an aryl group, the para-position of the aryl group is substituted by R8, the aryl group is a phenyl group, the R8 is an alkoxy group or the following shown groups, and the number of halogen, hydroxyl and carbon atoms in the R8 is 1-6. The compound also has an obvious effect on inhibiting a tumor sphere from a cancer patient with the colon cancer. In addition, the compound also has an obvious effect on inhibiting the migration and the moving ability of a colon cancer cell line. A novel medicine for treating the colon cancer is expected to be developed on the basis of the compound.