20834-59-7Relevant articles and documents
Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design
Hamada, Yoshio,Tagad, Harichandra D.,Nishimura, Yoshinori,Ishiura, Shoichi,Kiso, Yoshiaki
, p. 1130 - 1135 (2012/03/26)
Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of non-peptidic BACE1 inhibitors. Although these peptidic and non-peptidic inhibitors, with a hydroxymethylcarbonyl isostere as a substrate transition-state mimic, exhibited potent BACE1 inhibitory activities, their molecular-sizes appeared a little too big (molecular weight of >600 daltons) for developing practical anti-Alzheimer's disease drugs. To develop lower weight BACE1 inhibitors, a series of tripeptidic BACE1 inhibitors were devised using a design approach based on the conformation of a virtual inhibitor bound to the BACE1 active site, also called 'in-silico conformational structure-based design'. Although these tripeptidic BACE1 inhibitors contained some natural amino acid residues, they are expected to be useful as lead compounds for developing the next generation BACE1 inhibitors, due to their low molecular size and unique structural features compared with previously reported inhibitors.
Fragrance compositions containing 2-cyclohexyl-1,1-dimethyl ethanol esters
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, (2008/06/13)
A fragrance, having a 2-cyclohexyl-1,1-dimethyl ethanol derivative represented by formula (1), wherein R represents a hydrogen atom or an acetyl group, Me represents a methyl group and n represents an integer from 0 to 3, provides a very pleasing scent, has excellent stability in a product, and can be mixed well with other fragrances.
PHOTOCHEMICAL OXIDATION AND DIMERIZATION OF ALKYLBENZENES. SELECTIVE REACTIONS OF THE ALKYL SIDE GROUPS
Pasternak, Mordechai,Morduchowitz, Abraham
, p. 4275 - 4278 (2007/10/02)
Irradiations of alkylbenzene compounds in an oxygen atmosphere result exclusively in oxidation reactions, while in a less oxidative environment dimerization processes predominate.Under all conditions studied, the reactions took place only at one benzyl position.