20845-32-3

Basic information

• Product Name: 4-Hydroxymethyl-1-methyl-2-piperidone
• Synonyms: 4-Hydroxymethyl-1-methyl-2-piperidone;4-Hydroxymethyl-1-methyl-...;4-Hydroxymethyl-1-methyl-piperidin-2-one
• CAS NO: 20845-32-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 20845-32-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Hydroxymethyl-1-methyl-2-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxymethyl-1-methyl-2-piperidone(20845-32-3)
• EPA Substance Registry System: 4-Hydroxymethyl-1-methyl-2-piperidone(20845-32-3)

Safety Data

• Hazardous Substances Data: 20845-32-3(Hazardous Substances Data)

Usage

General Description

4-Hydroxymethyl-1-methyl-2-piperidone, also known as NMP, is a chemical compound with a molecular formula of C6H11NO2. It is a clear, colorless liquid with a faint amine odor and is soluble in water, alcohols, ethers, and other organic solvents. NMP is commonly used as a solvent in a variety of industrial processes, including petrochemical refining, electronics manufacturing, and pharmaceutical production. It is also used as a co-solvent in polymer processing and as a reagent in organic synthesis. NMP has potential reproductive and developmental toxicity, and should be handled and used with proper safety precautions.

Upstream product

• 20691-89-8 1-methyl-4-piperidinemethanol 

Relevant articles and documents

Supported Gold Nanoparticles for Efficient α-Oxygenation of Secondary and Tertiary Amines into Amides

Although the α-oxygenation of amines is a highly attractive method for the synthesis of amides, efficient catalysts suited to a wide range of secondary and tertiary alkyl amines using O2as the terminal oxidant have no precedent. This report describes a novel, green α-oxygenation of a wide range of linear and cyclic secondary and tertiary amines mediated by gold nanoparticles supported on alumina (Au/Al2O3). The observed catalysis was truly heterogeneous, and the catalyst could be reused. The present α-oxygenation utilizes O2as the terminal oxidant and water as the oxygen atom source of amides. The method generates water as the only theoretical by-product, which highlights the environmentally benign nature of the present reaction. Additionally, the present α-oxygenation provides a convenient method for the synthesis of18O-labeled amides using H218O as the oxygen source.