20845-80-1

Basic information

• Product Name: 2-Butanone, 1-chloro-4-phenyl-
• Synonyms: 1-Chlor-4-phenyl-butan-2-on;1-chloro-4-phenyl-2-butanone;1-chloro-4-phenyl-butan-2-one;2-Butanone,1-chloro-4-phenyl;4-phenyl-1-chlorobutan-2-one
• CAS NO: 20845-80-1
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Mol File: 20845-80-1.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 1-chloro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 1-chloro-4-phenyl-(20845-80-1)
• EPA Substance Registry System: 2-Butanone, 1-chloro-4-phenyl-(20845-80-1)

Safety Data

• Hazardous Substances Data: 20845-80-1(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 645-45-4 hydrocinnamic acid chloride 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 90878-19-6 phenethylmagnesium chloride 
• 2550-26-7 4-Phenyl-2-butanone 
• 2344-70-9 1-phenyl-3-butanol 
• 16520-62-0 4-Phenyl-1-butyne 
• 79-04-9 chloroacetyl chloride 
• 308796-14-7 phenethylzinc(II) bromide 
• 20296-07-5 1-hydroxy-4-phenyl-2-butanone 
• 501-52-0 3-Phenylpropionic acid 
• 82772-44-9 (4,4-Dichloro-3-methoxy-butyl)-benzene 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 104-53-0 3-phenyl-propionaldehyde 

Downstream Products

• 857420-96-3 2,5-diphenethyl-pyrrole-3-carbonitrile 
• 412309-09-2 (2,5-dioxo-4-phenethyl-imidazolidin-4-yl)-acetonitrile 
• 2550-26-7 4-Phenyl-2-butanone 
• 98055-06-2 2-(2-phenylethyl)-1H-indole 
• 26175-40-6 4-phenethyl-thiazol-2-ylamine 
• 1373121-58-4 C₁₈H₁₉ClN₂O₂ 
• 1373121-39-1 C₂₆H₂₄N₂O₃ 
• 1259944-09-6 3-hydroxy-2-phenylethylquinolin-4(1H)-one 
• 93434-80-1 1-phenyl-4-phenylsulphonylbutan-3-one 
• 102831-08-3 1-azido-4-phenylbutan-2-one 
• 122218-14-8 4,4'-diphenethyl-2,2'-diphenyl-5,5'-selanediyl-bis-thiazole 
• 22820-50-4 1-(isopropylamino)-4-phenylbutan-2-ol 

Relevant articles and documents

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Synthesis and reactivity of α-sulfenyl-β-chloroenones, including oxidation and Stille cross-coupling to form chalcone derivatives

The synthesis of a range of novel α-sulfenyl-β-chloroenones from the corresponding α-sulfenylketones, via a NCS mediated chlorination cascade, is described. The scope of the reaction has been investigated and compounds bearing alkyl- and arylthio substituents have been synthesised. In most instances, the Z α-sulfenyl-β-chloroenones were formed as the major products, while variation of the substituent at the β-carbon position led to an alteration in stereoselectivity. Stille cross-coupling with the Z α-sulfenyl-β-chloroenones led to selective formation of Z sulfenyl chalcones, while the E α-sulfenyl-β-chloroenones did not react under the same conditions. Oxidation of the Z α-sulfenyl-β-chloroenones was followed by isomerisation, leading to the E α-sulfinyl-β-chloroenones. Stille cross-coupling with the E α-sulfinyl-β-chloroenones produced the E sulfinyl chalcones. Either the E or Z sulfinyl chalcones can be obtained by altering the sequence of oxidation and Stille cross-coupling.

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).