208523-18-6

Basic information

• Product Name: 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (E)-2-butenedioate (2:1) (salt)
• Synonyms: 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (2E)-2-butenedioate (2:1) (salt);2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (E)-2-butenedioate (2:1) (salt)
• CAS NO: 208523-18-6
• Molecular Formula: C40H66N2O12
• Molecular Weight: 766.95824
• Mol File: 208523-18-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (E)-2-butenedioate (2:1) (salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (E)-2-butenedioate (2:1) (salt)(208523-18-6)
• EPA Substance Registry System: 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (E)-2-butenedioate (2:1) (salt)(208523-18-6)

Safety Data

• Hazardous Substances Data: 208523-18-6(Hazardous Substances Data)

Upstream product

• 66722-64-3 1-(p-2-isopropoxyethoxymethylphenoxy)-3-isopropylideneamino-propan-2-ol 
• 66722-57-4 2-((4-((2-isopropoxyethoxy)methyl)phenoxy)methyl)oxirane 
• 66722-65-4 N-[2-hydroxy-3-(p-2-isopropoxyethoxymethylphenoxy)-propyl]-N-isopropyl-acetamide 
• 111051-40-2 bisoprolol 
• 110-17-8 (2E)-but-2-enedioic acid 
• 177034-57-0 4-(2-isopropoxy-ethoxymethyl)-phenol 
• 111051-40-2 (+)-Bisoprolol 
• 99103-03-4 (-)-Bisoprolol 

Downstream Products

• 109-59-1 2-(1-methylethoxy)-ethanol 

Relevant articles and documents

Preparation method of chiral bisoprolol fumarate

The invention provides a preparation method of chiral bisoprolol fumarate. The preparation method comprises the following steps: preparation of (S)-bisoprolol fumarate and preparation of (R)-bisoprolol fumarate. According to the preparation method of the chiral bisoprolol fumarate, provided by the invention, isopropoxyethoxymethylphenol and sulfonyl chloride are subjected to esterification reaction to generate a sulfonate compound, the compound reacts with chiral epoxypropanol to generate a chiral epoxy compound, the compound is subjected to a ring-opening reaction to obtain chiral bisoprolol,and the chiral bisoprolol is subjected to a salt forming reaction to obtain chiral bisoprolol fumarate, wherein the obtained product is high in single configuration purity, so that the method has themain advantages that the raw materials are easy to obtain, the process is simple, economical and environment-friendly, and industrial production is facilitated.

MANUFACTURE OF BISOPROLOL AND INTERMEDIATES THEREFOR

A process for preparing bisoprolol comprises reacting oxazolidinone sulphonate with 4-hydroxybenzylaldehyde to form oxazolidinone benzaldehyde, forming oxazolidone benzylalcohol from oxazolidone benzaldehyde, and subsequently reacting oxazolidinone benzylalcohol with isopropyl oxitol to form bisoprolol base. Oxazolidone sulphonate and oxazolidone benzaldehyde are novel intermediates.

CsF in organic synthesis. The first and convenient synthesis of enantiopure bisoprolol by use of glycidyl nosylate

The regioselective substitution of glycidyl nosylate with phenols is catalyzed by CsF in the presence of K2CO3 in DMF; this reaction enables the first and convenient synthesis of enantiopure bisoprolol.