208655-73-6 Usage
Description
(1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is a boronic acid derivative featuring a triisopropylsilyl group attached to an indole ring. (1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is widely recognized for its role in organic chemistry, particularly as a reagent in the Suzuki-Miyaura coupling reaction, a method renowned for forming carbon-carbon bonds. Its unique structure, which includes the boronic acid functionality, positions it as a crucial building block in the synthesis of a variety of biologically active molecules, encompassing both pharmaceuticals and natural products.
Uses
Used in Pharmaceutical Synthesis:
(1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is utilized as a key intermediate in the synthesis of pharmaceuticals due to its ability to engage in cross-coupling reactions with aryl halides or triflates. This characteristic makes it an indispensable tool in creating complex organic molecules that are vital for developing new drugs and therapeutic agents.
Used in Organic Chemistry Research:
In the realm of organic chemistry research, (1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is employed as a reagent for the Suzuki-Miyaura coupling reaction. This reaction is pivotal for the formation of carbon-carbon bonds, which are fundamental in constructing the molecular frameworks of numerous organic compounds.
Used in Natural Product Synthesis:
(1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is also used as a building block in the synthesis of natural products. Its versatility in cross-coupling reactions facilitates the creation of complex molecular structures that are often found in naturally occurring bioactive compounds.
Used in the Development of Novel Chemical Entities:
(1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid serves as a valuable precursor in the development of novel chemical entities, particularly in the field of medicinal chemistry. Its participation in cross-coupling reactions allows for the design and synthesis of new molecules with potential therapeutic applications.
Overall, (1-(triisopropylsilyl)-1H-indol-3-yl)boronic acid is a multifaceted compound with applications spanning across various industries, including pharmaceuticals, organic chemistry research, and the synthesis of natural products, making it a cornerstone in the creation of complex organic molecules and potential therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 208655-73-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,8,6,5 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 208655-73:
(8*2)+(7*0)+(6*8)+(5*6)+(4*5)+(3*5)+(2*7)+(1*3)=146
146 % 10 = 6
So 208655-73-6 is a valid CAS Registry Number.
208655-73-6Relevant articles and documents
NOVEL PYRIDIN-2(1H)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF PAIN
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Page/Page column 15; 22-23, (2021/04/10)
The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.
NITROGENATED AROMATIC COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC ELECTRONIC DEVICE
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, (2013/07/31)
Provided are a nitrogen-containing aromatic heterocyclic compound useful as an organic semiconductor material and an organic electronic device using this compound. The nitrogen-containing aromatic heterocyclic compound has a fused indole skeleton represented by the following formula (1), the organic semiconductor material contains the said compound, and the organic electronic device uses the said organic semiconductor material. In general formula (1), X is N-A', O, S, or Se; A is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group exclusive of a fused heterocycle consisting of 4 rings or more; and R is a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group exclusive of a fused heterocycle consisting of 4 rings or more.
Synthesis of (3-indolyl)heteroaromatics by Suzuki-Miyaura coupling and their inhibitory activity in lipid peroxidation
Nishida, Atsushi,Miyashita, Naoki,Fuwa, Mihoko,Nakagawa, Masako
, p. 473 - 476 (2007/10/03)
A variety of (3-indolyl)heteroaromatic compounds were synthesized by Suzuki-Miyaura coupling of 3-indolylboronic acid and halogenated heteroaromatics. 2-(3-Indolyl)thiophene showed potent inhibitory activity against lipid peroxidation by rat liver microsome.
