208758-60-5

Basic information

• Product Name: N-{7-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-6-oxo-6,7-dihydro-1H-purin-2-yl}-acetamide
• CAS NO: 208758-60-5
• Molecular Weight: 535.675
• Mol File: 208758-60-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{7-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-6-oxo-6,7-dihydro-1H-purin-2-yl}-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{7-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-6-oxo-6,7-dihydro-1H-purin-2-yl}-acetamide(208758-60-5)
• EPA Substance Registry System: N-{7-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-6-oxo-6,7-dihydro-1H-purin-2-yl}-acetamide(208758-60-5)

Safety Data

• Hazardous Substances Data: 208758-60-5(Hazardous Substances Data)

Upstream product

• 119879-74-2 (R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-propan-2-ol 
• 19962-37-9 N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide 
• 201732-38-9 ((R)-3-Benzyloxy-2-chloromethoxy-propoxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 208758-62-7 N-(7-{(S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethoxymethyl}-6-oxo-6,7-dihydro-1H-purin-2-yl)-acetamide 

Relevant articles and documents

Synthesis and triplex forming properties of an acyclic N7-glycosylated guanine nucleoside

A chiral acyclic nucleoside, one in which the ribose carbohydrate has been replaced with a glycerol-based linker, is prepared by glycosylating guanine at the N7-nitrogen. The stereochemically pure derivative is converted to a DMT-protected phosphoramidite for incorporation into DNA sequences. Sequence containing the acyclic N7-dG nucleoside are capable of forming DNA triplexes in which it is likely that the N1-H and N2-amino groups of the N7-dG are involved in recognition of the guanine base in G-C base pairs.