20876-31-7 Usage
Description
Benzeneacetic acid, 3-methoxy-2-nitro-, also known as 3-Methoxy-2-nitrobenzoic acid, is a chemical compound with the molecular formula C9H9NO5. It is a bright yellow crystalline solid that is often used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is known for its anti-inflammatory and analgesic properties, making it a valuable component in the development of pain relief medications.
Uses
Used in Pharmaceutical Industry:
Benzeneacetic acid, 3-methoxy-2-nitrois used as an intermediate in the synthesis of various drugs for its anti-inflammatory and analgesic properties. It plays a crucial role in the production of pain relief medications, contributing to the development of effective treatments for various conditions.
Used in Organic Synthesis:
Benzeneacetic acid, 3-methoxy-2-nitroalso serves as a precursor in the synthesis of other organic compounds. Its unique chemical structure allows it to be a versatile building block in the creation of a wide range of chemical products.
Safety Precautions:
It is important to handle Benzeneacetic acid, 3-methoxy-2-nitrowith caution, as it is toxic and may cause irritation to the skin and eyes. Proper safety measures should be taken during its production, handling, and use to minimize potential health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 20876-31-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,8,7 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20876-31:
(7*2)+(6*0)+(5*8)+(4*7)+(3*6)+(2*3)+(1*1)=107
107 % 10 = 7
So 20876-31-7 is a valid CAS Registry Number.
20876-31-7Relevant articles and documents
Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors
Mologni, Luca,Rostagno, Roberta,Brussolo, Stefania,Knowles, Phillip P.,Kjaer, Svend,Murray-Rust, Judith,Rosso, Enrico,Zambon, Alfonso,Scapozza, Leonardo,McDonald, Neil Q.,Lucchini, Vittorio,Gambacorti-Passerini, Carlo
experimental part, p. 1482 - 1496 (2010/04/29)
The synthesis, structure-activity relationships (SAR) and structural data of a series of indolin-2-one inhibitors of RET tyrosine kinase are described. These compounds were designed to explore the available space around the indolinone scaffold within RET active site. Several substitutions at different positions were tested and biochemical data were used to draw a molecular model of steric and electrostatic interactions, which can be applied to design more potent and selective RET inhibitors. The crystal structures of RET kinase domain in complex with three inhibitors were solved. All three compounds bound in the ATP pocket and formed two hydrogen bonds with the kinase hinge region. Crystallographic analysis confirmed predictions from molecular modelling and helped refine SAR results. These data provide important information for the development of indolinone inhibitors for the treatment of RET-driven cancers.
