20883-91-4

Basic information

• Product Name: p-Diaethylamino-zimtsaeure-methylester
• Synonyms: p-Diaethylamino-zimtsaeure-methylester
• CAS NO: 20883-91-4
• Molecular Weight: 233.31
• Mol File: 20883-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-Diaethylamino-zimtsaeure-methylester(CAS DataBase Reference)
• NIST Chemistry Reference: p-Diaethylamino-zimtsaeure-methylester(20883-91-4)
• EPA Substance Registry System: p-Diaethylamino-zimtsaeure-methylester(20883-91-4)

Safety Data

• Hazardous Substances Data: 20883-91-4(Hazardous Substances Data)

Upstream product

• 20883-30-1 4-diethylaminophenylmercury chloride 
• 292638-85-8 acrylic acid methyl ester 
• 120-21-8 4-Diethylaminobenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 22411-59-2 trans-4-(diethylamino)cinnamaldehyde 

Relevant articles and documents

Synthesis of 3-[4-(dimethylamino)phenyl]alkyl-2-oxindole derivatives and their effects on neuronal cell death

Novel 3-[4-(dimethylamino)phenyl]alkyl-2-oxindole analogs were synthesized by either of the following two pathways: (1) a sequence of Knoevenagel condensation of oxindole with (4-dimethylamino)cinnamaldehyde–hydrogenation, or (2) alkylation of oxindole dianion with [(4-dimethylamino)phenyl]alkyl halides. Subsequent alkylation at C-3 and/or N-1 of the oxindole skeleton by anion-based methods provided additional substituted derivatives for structure-activity relationship studies. Their effects on neuronal cell death induced by oxidative stress were evaluated by lactate dehydrogenase assay. Compounds with the alkyl chain length of 2–4 significantly suppressed the neuronal cell death. No significant change occurred in the activity by substitution with less-polar groups. The stereochemistry at C-3 of the oxindole core was also irrelevant for the neuroprotective effects of these compounds.