20883-98-1

Basic information

• Product Name: 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER
• Synonyms: METHYL-C-COUMARATE;METHYL 2-HYDROXYCINNAMATE;METHYL 2-COUMARATE;3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER;2-Propenoic acid, 3-(2-hydroxyphenyl)-, methyl ester;Cinnamic acid, o-hydroxy-, methyl ester;Methyl (2E)-3-(2-hydroxyphenyl)-2-propenoate;Methyl ester of o-Hydroxycinnamic acid
• CAS NO: 20883-98-1
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Product Categories: Aromatic Esters
• Mol File: 20883-98-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 308.2°Cat760mmHg
• Flash Point: 133.7°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 0.000379mmHg at 25°C
• Refractive Index: 1.592
• PKA: 8.56±0.30(Predicted)
• CAS DataBase Reference: 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER(20883-98-1)
• EPA Substance Registry System: 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER(20883-98-1)

Safety Data

• Hazardous Substances Data: 20883-98-1(Hazardous Substances Data)

Usage

General Description

3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER is a chemical compound that belongs to the ester family. It is derived from acrylic acid and contains a hydroxyphenyl group. 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER is commonly used in the manufacturing of fragrances, flavors, and other cosmetic products. It is also used as a raw material in the production of plastics, coatings, and adhesives. Additionally, it has applications in organic synthesis and pharmaceuticals. 3-(2-HYDROXY-PHENYL)-ACRYLIC ACID METHYL ESTER is considered to have low toxicity and is generally safe for use in these applications. However, it must be handled with caution and in accordance with safety guidelines to prevent any health or environmental hazards.

InChI:InChI=1/C10H10O3/c1-13-10(12)7-6-8-4-2-3-5-9(8)11/h2-7,11H,1H3/b7-6+

Upstream product

• 90-02-8 salicylaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 495-79-4 2-hydroxycinnamic acid 
• 16045-88-8 boron trifluoride methanol complex 
• 936563-48-3 2-(2-(methoxycarbonyl)allyloxy)-iodobenzene 
• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 
• 533-58-4 2-Iodophenol 
• 108-95-2 phenol 
• 95-56-7 2-hydroxybromobenzene 
• 75961-78-3 1-formyl-1,2-oxido-4-cyclohexene 
• 186581-53-3 diazomethane 
• 138-24-9 phenyltrimethylammonium chloride 
• 90-03-9 (2-hydroxyphenyl)mercury chloride 

Downstream Products

• 91-64-5 coumarin 
• 51531-47-6 (E)-3-(2-Oxiranylmethoxy-phenyl)-acrylic acid methyl ester 
• 271-89-6 1-benzofurane 
• 87950-15-0 (E)-3-(2-Benzyloxy-phenyl)-acrylic acid methyl ester 
• 874333-05-8 C₂₈H₃₈N₄O₄ 
• 1065018-66-7 C₂₃H₂₉NO₆ 
• 1047666-12-5 C₃₀H₄₀N₄O₄ 

Relevant articles and documents

Phenol compound ortho-position direct olefination method and olefinated phenol compound

The invention relates to a phenol compound ortho-position direct olefination method and an olefinated phenol compound prepared with the method. The method comprises the steps that a phenol compound shown by the formula (II) and an olefin compound shown by

Microwave-Assisted Synthesis of Phenylpropanoids and Coumarins: Total Synthesis of Osthol

Herein we describe a one-pot microwave-assisted method for the synthesis of cinnamic acid and coumarin derivatives. The synthesis begins with an aldehyde synthon, and the chosen reaction conditions determine whether a cinnamic acid or coumarin derivative is formed. A regioselective Claisen rearrangement was also efficiently incorporated into the synthetic sequence to further increase the complexity of the product. Notably, this approach provides high product yields and selectivities without the need of a phenol protecting group.

Intermediates for macrocyclic compounds

The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.