208844-36-4

Basic information

• Product Name: N-[(1R)-2-(1,1-dimethylpropyl)oxy-1-phenylethyl]-4-hexynamide
• Synonyms: N-[(1R)-2-(1,1-dimethylpropyl)oxy-1-phenylethyl]-4-hexynamide
• CAS NO: 208844-36-4
• Molecular Weight: 301.429
• Mol File: 208844-36-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(1R)-2-(1,1-dimethylpropyl)oxy-1-phenylethyl]-4-hexynamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R)-2-(1,1-dimethylpropyl)oxy-1-phenylethyl]-4-hexynamide(208844-36-4)
• EPA Substance Registry System: N-[(1R)-2-(1,1-dimethylpropyl)oxy-1-phenylethyl]-4-hexynamide(208844-36-4)

Safety Data

• Hazardous Substances Data: 208844-36-4(Hazardous Substances Data)

Upstream product

• 132645-60-4 tert-butyl(hex-4-yn-1-yloxy)dimethylsilane 
• 928-93-8 4-hexyn-1-ol 
• 41143-12-8 hex-4-ynoic acid 
• 85355-30-2 2-(R,S)-(hex-4-ynyloxy)tetrahydropyran 
• 62992-46-5 1-(tetrahydropyranyloxy)-4-pentyn 
• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 

Relevant articles and documents

Stereoselective synthesis of 5-(1-hydroxyalkyl)-2-pyrrolidinones utilizing oxidation of 5-alkylidene-2-pyrrolidinones to acyliminium ion precursors

A general method was devised for the LiN(TMS)2/AgOTf (=2:1)-catalyzed intramolecular (5-exo-dig) cyclization of β-alkynylamides 1 possessing alkyl, aryl or no functional groups at the terminal alkynes, to 5-alkylidene-2-pyrrolidinones 2. These 5-alkylidene-2-pyrrolidinones were oxidized to the diol-type alkoxylactams 3 by dimethyldioxirane (DMD) or mCPBA in MeOH. These alkoxylactams are useful as tertiary N-acyliminium ion precursors for the synthesis of threo-5-(1-hydroxyalkyl)-2-pyrrolidinone derivatives 5. (C) 2000 Elsevier Science Ltd.