20887-03-0

Basic information

• Product Name: N-(2-aminobenzyl)-4-chloroaniline
• Synonyms: N-(2-aminobenzyl)-4-chloroaniline
• CAS NO: 20887-03-0
• Molecular Weight: 232.713
• Mol File: 20887-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-aminobenzyl)-4-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminobenzyl)-4-chloroaniline(20887-03-0)
• EPA Substance Registry System: N-(2-aminobenzyl)-4-chloroaniline(20887-03-0)

Safety Data

• Hazardous Substances Data: 20887-03-0(Hazardous Substances Data)

Upstream product

• 17064-76-5 N-(4-chlorophenyl)-1-(2-nitrophenyl)methanimine 
• 552-89-6 2-nitro-benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 151383-60-7 4-chloro-N-(2-nitrobenzyl)aniline 
• 4943-86-6 2-amino-N-(4-chlorophenyl)benzamide 

Relevant articles and documents

Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines

A continuous-flow process for the in situ on-demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide that makes use of membrane-separation technology is described. In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate–bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in-line FTIR technology. With the Br2 and BrCN generators connected in series, 0.2 mmol BrCN per minute was produced, which corresponds to a 0.8 m solution of BrCN in dichloromethane. The modular Br2/BrCN generator was employed for the synthesis of a diverse set of biologically relevant five- and six-membered cyclic amidines and guanidines. The set-up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi-batch mode.