20914-69-6

Basic information

• Product Name: 2-Methyl-[1,2,4]triazolo[1,5-a]pyrazine
• Synonyms: 2-Methyl-[1,2,4]triazolo[1,5-a]pyrazine
• CAS NO: 20914-69-6
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.13864
• Mol File: 20914-69-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 132 °C
• Appearance: /
• Density: 1.39g/cm³
• Refractive Index: 1.722
• Storage Temp.: 2-8°C
• PKA: 0.85±0.30(Predicted)
• CAS DataBase Reference: 2-Methyl-[1,2,4]triazolo[1,5-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-[1,2,4]triazolo[1,5-a]pyrazine(20914-69-6)
• EPA Substance Registry System: 2-Methyl-[1,2,4]triazolo[1,5-a]pyrazine(20914-69-6)

Safety Data

• Hazardous Substances Data: 20914-69-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 12, p. 107, 1975 DOI: 10.1002/jhet.5570120118

InChI:InChI=1/C6H6N4/c1-5-8-6-4-7-2-3-10(6)9-5/h2-4H,1H3

Upstream product

• 21352-21-6 2-(N-acetylamino)pyrazine 
• 36016-40-7 mesitylenesulfonylhydroxylamine 
• 68675-32-1 N,N-dimethyl-N'-pyrazin-2-yl-acetamidine 
• 83412-71-9 N-(pyrazin-2 yl) acetamide oxime 

Relevant articles and documents

Regioselectivity in the amination of azines: Reaction of pyrazine derivatives with O-mesitylenesulfonylhydroxylamine

Treatment of 2-X-substituted pyrazines [X = H, Me, Et, Pr, i-Pr, t-Bu, MeCH(OH), H2N, AcNH] with O-mesitylenesulfonylhydroxylamine gave the corresponding 2-X- and 3-X-(1-amino)pyrazin-1-ium mesitylenesulfonates. 2-Alkylpyrazines (X = Me, Et, Pr, i-Pr) displayed a correlation between the logarithms of the concentration ratio of 2- and 3-substituted cations and substituent steric constants. Wider series of substituted pyrazines [X = H, Me, Et, Pr, i-Pr, MeCH(OH), H2N, AcNH] conformed to a multiparameter correlation between the logarithms of the concentration ratio of 2- and 3-substituted cations, on the one hand, and substituent constants σI, σR?, and E s?, on the other. The obtained data on the regioselectivity of amination of pyrazines were interpreted in terms of DFT/PBE/3Z quantum-chemical calculations. Pleiades Publishing, Ltd., 2011.

Quinoline derivatives as neurokinin receptor antagonists

The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

Synthesis of s-triazolo(1,5-a)pyrazine derivates and cytokinin activity.

-