20916-16-9

Basic information

• Product Name: Acetamide, 2-(4-nitrophenoxy)-N-(phenylmethyl)-
• CAS NO: 20916-16-9
• Molecular Formula: C15H14N2O4
• Molecular Weight: 286.287
• Mol File: 20916-16-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-(4-nitrophenoxy)-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-(4-nitrophenoxy)-N-(phenylmethyl)-(20916-16-9)
• EPA Substance Registry System: Acetamide, 2-(4-nitrophenoxy)-N-(phenylmethyl)-(20916-16-9)

Safety Data

• Hazardous Substances Data: 20916-16-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 100-02-7 4-nitro-phenol 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 1798-11-4 4-nitrophenoxyacetic acid 

Downstream Products

• 936632-84-7 1-deoxy-1-(2-chloro-6-{4-[(benzylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 936632-79-0 1-deoxy-1-(6-{4-[(benzylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 168897-16-3 2-(4-aminophenoxy)-N-benzylacetamide 

Relevant articles and documents

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.

AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES

Amidine derivative compounds of formula I as defined in the Specification having nitric oxide synthetase inhibitory activity as well as processes for the preparation of and compositions containing said compounds are described