20916-70-5

Basic information

• Product Name: 4-tert-butyl-N,N-diethylbenzamide
• Synonyms: Benzamide, 4-(1,1-dimethylethyl)-N,N-diethyl-
• CAS NO: 20916-70-5
• Molecular Formula: C₁₅H₂₃NO
• Molecular Weight: 233.3492
• Mol File: 20916-70-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 347.8°C at 760 mmHg
• Flash Point: 148.7°C
• Density: 0.954g/cm³
• Vapor Pressure: 5.24E-05mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 4-tert-butyl-N,N-diethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-N,N-diethylbenzamide(20916-70-5)
• EPA Substance Registry System: 4-tert-butyl-N,N-diethylbenzamide(20916-70-5)

Safety Data

• Hazardous Substances Data: 20916-70-5(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 121-44-8 triethylamine 
• 109-89-7 diethylamine 
• 1710-98-1 p-tert-butyl benzoyl chloride 

Downstream Products

• 939-97-9 4-tert-Butylbenzaldehyde 
• 1361941-30-1 5-tert-butyl-2-(2-(hydroxymethyl)-3-(1-methyl-5-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoindolin-1-one 
• 1361941-29-8 2-(5-amino-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(5-tert-butyl-1-oxoisoindolin-2-yl)benzyl acetate 
• 1361941-28-7 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate 
• 1361941-26-5 5-tert-butyl-2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(5-(2-oxopiperazin-1-yl)pyridin-2-ylamino)-1,6-dihydropyridin-3-yl)phenyl)isoindolin-1-one 
• 1361941-25-4 5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one 
• 1361941-23-2 2-(3-(5-(5-(azetidin-3-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)-5-tert-butylisoindolin-1-one 
• 1361941-22-1 tert-butyl 3-(6-(5-(3-(5-tert-butyl-1-oxoisoindolin-2-yl)-2-(hydroxy-methyl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-3-yl)azetidine-1-carboxylate 
• 1361941-15-2 5-tert-butyl-2-(3-(5-(1-cyclopropyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one 
• 1361941-04-9 5-tert-butyl-2-(2-(hydroxymethyl)-3-(4-methyl-5-oxo-6-(pyridin-3-ylamino)-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one 
• 1361386-53-9 methyl 5-tert-butyl-2-(diethylcarbamoyl)benzylcarbamate 
• 1361386-61-9 5-tert-butyl-2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyridin-2-ylamino)-dihydropyridazin-3-1,6-yl)phenyl)isoindolin-1-one 
• 1361386-58-4 5-tert-butyl-2-(3-(5-(1-ethyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6dihydropyridazin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one 
• 1361386-56-2 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 

Relevant articles and documents

HMF and furfural: Promising platform molecules in rhodium-catalyzed carbonylation reactions for the synthesis of furfuryl esters and tertiary amides

A biomass involved rhodium-catalyzed carbonylative synthesis of furfuryl esters and tertiary amides has been developed. 5-Hydroxymethylfurfural (HMF) was used as both substrate and CO surrogate for the first time in a carbonylation reaction, and both alkyl and aryl iodides were tolerated well to afford the desired furfuryl esters in moderate to good yields. In addition, furfural was also utilized as a CO source for the synthesis of tertiary amides. A variety of tertiary amides were obtained in moderate to excellent yields with good functional groups compatibility. Notably, tertiary amines were used as the amine source through a C[sbnd]N bond cleavage pathway in the absence of additional oxidant.

Mild conversion of tertiary amides to aldehydes using Cp2Zr(H)Cl (Schwartz's reagent)

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