20928-26-1Relevant articles and documents
Highly alkyl-selective addition to ketones with magnesium ate complexes derived from Gignard reagents
Hatano, Manabu,Matsumura, Tokihiko,Ishihara, Kazuaki
, p. 573 - 576 (2007/10/03)
(Chemical Equation Presented) A highly efficient alkyl-selective addition to ketones with magnesium ate complexes derived from Grignard reagents and alkyllithiums is described. The nucleophilicity of R in R3MgLi is remarkably increased compared to that of the original RLi or RMgX, while the basicity of R3MgLi is decreased. Furthermore, a highly R-selective addition to ketones is demonstrated using RMe2MgLi in place of R 3MgLi.