209329-11-3 Usage
Description
(R)-2-Azetidinemethanol, also known as (R)-2-(hydroxymethyl)azetidinium, is an organic compound with a unique four-membered azetidine ring and a hydroxymethyl group. It is a chiral molecule, with the (R)-configuration being the biologically active form. (R)-2-Azetidinemethanol is known for its versatile reactivity and is a key building block in the synthesis of various pharmaceuticals and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
(R)-2-Azetidinemethanol is used as a key intermediate in the synthesis of various compounds, particularly those that act as neprilysin inhibitors. These inhibitors are crucial in the treatment of hypertension, heart failure, and renal disease, either as standalone therapies or in combination with other treatments. The compound's unique structure and reactivity make it an essential component in the development of new and effective medications for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 209329-11-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,3,2 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 209329-11:
(8*2)+(7*0)+(6*9)+(5*3)+(4*2)+(3*9)+(2*1)+(1*1)=123
123 % 10 = 3
So 209329-11-3 is a valid CAS Registry Number.
209329-11-3Relevant articles and documents
Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic
Lynch, John K.,Holladay, Mark W.,Ryther, Keith B.,Bai, Hao,Hsiao, Chi-Nung,Morton, Howard E.,Dickman, Daniel A.,Arnold, William,King, Steven A.
, p. 2791 - 2794 (2007/10/03)
A concise asymmetric synthesis of (R)-2-chloro-5-(2- azetidinylmethoxy)pyridine (ABT-594) is presented in which the key intermediate t-butoxycarbonyl protected (2R)-azetidinylalcohol is obtained in three steps from the dibenzyl ester of D-aspartic acid in 44% yield and >99% ee.
