209412-08-8Relevant articles and documents
The discovery of VX-745: A novel and selective p38α kinase inhibitor
Duffy, John P.,Harrington, Edmund M.,Salituro, Francesco G.,Cochran, John E.,Green, Jeremy,Gao, Huai,Bemis, Guy W.,Evindar, Ghotas,Galullo, Vincent P.,Ford, Pamella J.,Germann, Ursula A.,Wilson, Keith P.,Bellon, Steven F.,Chen, Guanging,Taslimi, Paul,Jones, Peter,Huang, Cassey,Pazhanisamy,Wang, Yow-Ming,Murcko, Mark A.,Su, Michael S.S.
supporting information; experimental part, p. 758 - 763 (2011/12/03)
The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to t
