20977-05-3

Basic information

• Product Name: Escin, monosodium salt
• Synonyms: Sodium Aescinate for Injection;Escin, monosodium salt;Sodium escinate;Aescin polysulphate sodium salt;Entsufon SodiuM;Aescin monosodium salt
• CAS NO: 20977-05-3
• Molecular Formula: C53H82O36S4
• Molecular Weight: 0
• EINECS: 244-133-4
• Product Categories: standardized herbal extract;Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).
• Mol File: 20977-05-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 250-252 °C
• Appearance: COA
• CAS DataBase Reference: Escin, monosodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Escin, monosodium salt(20977-05-3)
• EPA Substance Registry System: Escin, monosodium salt(20977-05-3)

Safety Data

• Hazardous Substances Data: 20977-05-3(Hazardous Substances Data)

Usage

Description

Escin, monosodium salt, also known as E658790, is a naturally occurring saponin derived from the seeds of the Aesculus hippocastanum tree, commonly known as the horse chestnut. It is characterized by its bioactive properties, which include anti-inflammatory, antioxidant, and vascular protective effects. The monosodium salt form of Escin enhances its solubility and bioavailability, making it a versatile compound for various pharmaceutical and therapeutic applications.

Uses

Used in Pharmaceutical Applications:
Escin, monosodium salt is used as a therapeutic agent for the treatment of various conditions, including ischemic damage, hemorrhoids, and trauma. Its application is also beneficial for patients recovering from surgery, as it aids in the healing process and reduces inflammation.
Used in Anticancer Treatments:
In the field of oncology, Escin, monosodium salt is utilized as a treatment for adenocarcinoma cell lines. It exhibits anti-cancer properties by modulating cellular signaling pathways and disrupting the growth and proliferation of cancer cells. Its use in combination with other chemotherapeutic agents may enhance the overall efficacy of cancer treatment and improve patient outcomes.
Used in Drug Delivery Systems:
To improve the delivery and bioavailability of Escin, monosodium salt, researchers are exploring the development of novel drug delivery systems. These systems may include encapsulation in nanoparticles or other carriers, which can enhance the compound's solubility, stability, and targeted delivery to specific tissues or cells. This approach has the potential to increase the therapeutic benefits of Escin, monosodium salt while minimizing potential side effects.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Na2O. See also SAPONIN and other escin entries.

InChI:InChI=1/C54H84O23.Na/c1-22(23(2)71-24(3)57)45(68)70-21-54-26-16-49(4,5)43(42(54)65)73-32(54)17-53(9)25(26)10-11-30-50(6)14-13-31(51(7,20-56)29(50)12-15-52(30,53)8)74-48-40(76-46-36(62)33(59)27(58)19-69-46)38(64)39(41(77-48)44(66)67)75-47-37(63)35(61)34(60)28(18-55)72-47;/h10,22-23,26-43,46-48,55-56,58-65H,11-21H2,1-9H3,(H,66,67);/q;+1/t22?,23?,26?,27-,28-,29?,30?,31?,32-,33+,34-,35+,36-,37-,38+,39+,40-,41+,42?,43-,46+,47-,48-,50?,51-,52?,53-,54?;/m1./s1